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@article{1368294,
author = {Čechová, Eliška and Scheringer, Martin and Seifertová, Marta and Mikeš, Ondřej and Kroupová, Kristýna and Kuta, Jan and Forns, Joan and Eggesbo, Merete and Quaak, Ilona and de Cock, Marijke and van de Bor, Margot and Patayova, Henrieta and Murínová, L'ubica and Kočan, Anton},
article_location = {AMSTERDAM},
article_number = {February},
doi = {http://dx.doi.org/10.1016/j.scitotenv.2016.11.046},
keywords = {Developmental neurotoxicity; Daily intakes; Methylmercury; Organochlorine compounds; Pharmacokinetic model},
language = {eng},
issn = {0048-9697},
journal = {Science of the Total Environment},
title = {Developmental neurotoxicants in human milk: Comparison of levels and intakes in three European countries},
url = {http://www.sciencedirect.com/science/article/pii/S0048969716324779},
volume = {579},
year = {2017}
}
TY - JOUR
ID - 1368294
AU - Čechová, Eliška - Scheringer, Martin - Seifertová, Marta - Mikeš, Ondřej - Kroupová, Kristýna - Kuta, Jan - Forns, Joan - Eggesbo, Merete - Quaak, Ilona - de Cock, Marijke - van de Bor, Margot - Patayova, Henrieta - Murínová, L'ubica - Kočan, Anton
PY - 2017
TI - Developmental neurotoxicants in human milk: Comparison of levels and intakes in three European countries
JF - Science of the Total Environment
VL - 579
IS - February
SP - 637-645
EP - 637-645
PB - Elsevier Science BV
SN - 00489697
KW - Developmental neurotoxicity
KW - Daily intakes
KW - Methylmercury
KW - Organochlorine compounds
KW - Pharmacokinetic model
UR - http://www.sciencedirect.com/science/article/pii/S0048969716324779
L2 - http://www.sciencedirect.com/science/article/pii/S0048969716324779
N2 - Developmental neurotoxicants (DNTs), such as methylmercury (MeHg), polychlorinated biphenyls (PCBs) and selected organochlorine pesticides (OCPs), have gained increasing interest recently due to their possible relation to developmental disorders in children, which are increasing worldwide. We analyzed levels of 14 developmental neurotoxicants in human milk samples from Slovakia (n = 37), the Netherlands (n = 120) and Norway (n = 388). Positive identification for most target analytes was >95% in all samples. In all three countries MeHg was measured for the first time in mother milk. The highest MeHg levels were observed in Norway (39 pg g(-1), ww) with the highest fish consumption. Levels of indicator PCBs (iPCBs, sum of PCB 28, 52, 101, 138, 153 and 180), HCB and DDE + DDT were 2-4 times higher in Slovakia compared to the Netherlands or Norway. The levels of MeHg and organochlorine compounds were used for calculations of weekly or daily intakes (top-down approach) by means of pharmacokinetic modeling. The intakes ranged from 0.014 to 0.142 mu g kg(bw)(-1) week(-1) for MeHg and from 0.043 to 17.4 mu g kg(bw)(-1) day(-1) for organochlotine compounds in all three countries. Intakes of iPCBs exceeded a tolerable daily intake of 10 ng kgbw day(-1) in 16% of the Slovak participants. The top-down estimates were compared with bottom-up intakes based on national dietaty estimates and the results showed good consistency between both approaches, with the bottom-up intakes exceeding the top-down by a factor of maximum 3.8 for iPCBs in the Netherlands and 3.9 for HCB in Slovakia. This confirms that food consumption in all three countries represents the dominant pathway of exposure to these developmental neurotoxicants.
ER -
ČECHOVÁ, Eliška, Martin SCHERINGER, Marta SEIFERTOVÁ, Ondřej MIKEŠ, Kristýna KROUPOVÁ, Jan KUTA, Joan FORNS, Merete EGGESBO, Ilona QUAAK, Marijke DE COCK, Margot VAN DE BOR, Henrieta PATAYOVA, L'ubica MURÍNOVÁ and Anton KOČAN. Developmental neurotoxicants in human milk: Comparison of levels and intakes in three European countries. \textit{Science of the Total Environment}. AMSTERDAM: Elsevier Science BV, 2017, vol.~579, February, p.~637-645. ISSN~0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2016.11.046.
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