CSÁVÁS, Magdolna, Lenka MALINOVSKÁ, Florent PERRET, Milán GYURKÓ, Zita Tünde ILLYÉS, Michaela WIMMEROVÁ and Anikó BORBÁS. Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia. Carbohydrate Research. Elsevier Science, 2017, vol. 437, January 2017, p. 1-8. ISSN 0008-6215. Available from: https://dx.doi.org/10.1016/j.carres.2016.11.008.
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Basic information
Original name Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia
Authors CSÁVÁS, Magdolna (348 Hungary), Lenka MALINOVSKÁ (203 Czech Republic, belonging to the institution), Florent PERRET (250 France), Milán GYURKÓ (348 Hungary), Zita Tünde ILLYÉS (348 Hungary), Michaela WIMMEROVÁ (203 Czech Republic, guarantor, belonging to the institution) and Anikó BORBÁS (348 Hungary).
Edition Carbohydrate Research, Elsevier Science, 2017, 0008-6215.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.074
RIV identification code RIV/00216224:14740/17:00094607
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1016/j.carres.2016.11.008
UT WoS 000392557900001
Keywords in English Burkholderia cenocepacia; Mannose-binding lectin; Glycoclusters; Click reaction; Anti-adhesion therapy
Tags CF BIC
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 15/3/2018 15:27.
Abstract
The opportunistic Gram-negative bacterium Burkholderia cenocepacia causes lethal infections in cystic fibrosis patients. Multivalent mannoside derivatives were prepared as potential inhibitors of lectin BC2L-A, one of the virulence factors deployed by B. cenocepacia in the infection process. The interaction between the glycoclusters and the mannose binding BC2L-A lectin from B. cenocepacia was examined by isothermal microcalorimetry, surface plasmon resonance, inhibition of yeast agglutination and analytical ultracentrifugation.
Links
GA15-17572S, research and development projectName: Glykoklastry kalix[4]aren/C-oligosacharidy pro studium selektivity interakcí s lektiny
Investor: Czech Science Foundation
LM2015043, research and development projectName: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)
Investor: Ministry of Education, Youth and Sports of the CR
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