Tri- and tetravalent mannoclusters cross-link and aggregate
BC2L-A lectin from Burkholderia cenocepacia

J 2017

Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia

CSÁVÁS, Magdolna, Lenka MALINOVSKÁ, Florent PERRET, Milán GYURKÓ, Zita Tünde ILLYÉS et. al.

Basic information

Original name

Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia

Authors

CSÁVÁS, Magdolna (348 Hungary), Lenka MALINOVSKÁ (203 Czech Republic, belonging to the institution), Florent PERRET (250 France), Milán GYURKÓ (348 Hungary), Zita Tünde ILLYÉS (348 Hungary), Michaela WIMMEROVÁ (203 Czech Republic, guarantor, belonging to the institution) and Anikó BORBÁS (348 Hungary)

Edition

Carbohydrate Research, Elsevier Science, 2017, 0008-6215

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.074

RIV identification code

RIV/00216224:14740/17:00094607

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.carres.2016.11.008

UT WoS

000392557900001

Keywords in English

Burkholderia cenocepacia; Mannose-binding lectin; Glycoclusters; Click reaction; Anti-adhesion therapy

Abstract

V originále

The opportunistic Gram-negative bacterium Burkholderia cenocepacia causes lethal infections in cystic fibrosis patients. Multivalent mannoside derivatives were prepared as potential inhibitors of lectin BC2L-A, one of the virulence factors deployed by B. cenocepacia in the infection process. The interaction between the glycoclusters and the mannose binding BC2L-A lectin from B. cenocepacia was examined by isothermal microcalorimetry, surface plasmon resonance, inhibition of yeast agglutination and analytical ultracentrifugation.

Links

GA15-17572S, research and development project

Name: Glykoklastry kalix[4]aren/C-oligosacharidy pro studium selektivity interakcí s lektiny

Investor: Czech Science Foundation

LM2015043, research and development project

Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

CSÁVÁS, Magdolna, Lenka MALINOVSKÁ, Florent PERRET, Milán GYURKÓ, Zita Tünde ILLYÉS, Michaela WIMMEROVÁ and Anikó BORBÁS. Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia. Carbohydrate Research. Elsevier Science, 2017, vol. 437, January 2017, p. 1-8. ISSN 0008-6215. Available from: https://dx.doi.org/10.1016/j.carres.2016.11.008.

@article{1368358,
   author = {Csávás, Magdolna and Malinovská, Lenka and Perret, Florent and Gyurkó, Milán and Illyés, Zita Tünde and Wimmerová, Michaela and Borbás, Anikó},
   article_number = {January 2017},
   doi = {http://dx.doi.org/10.1016/j.carres.2016.11.008},
   keywords = {Burkholderia cenocepacia; Mannose-binding lectin; Glycoclusters; Click reaction; Anti-adhesion therapy},
   language = {eng},
   issn = {0008-6215},
   journal = {Carbohydrate Research},
   title = {Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia},
   url = {https://www.sciencedirect.com/science/article/pii/S0008621516303160?via%3Dihub},
   volume = {437},
   year = {2017}
}

TY  - JOUR
ID  - 1368358
AU  - Csávás, Magdolna - Malinovská, Lenka - Perret, Florent - Gyurkó, Milán - Illyés, Zita Tünde - Wimmerová, Michaela - Borbás, Anikó
PY  - 2017
TI  - Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia
JF  - Carbohydrate Research
VL  - 437
IS  - January 2017
SP  - 1-8
EP  - 1-8
PB  - Elsevier Science
SN  - 00086215
KW  - Burkholderia cenocepacia
KW  - Mannose-binding lectin
KW  - Glycoclusters
KW  - Click reaction
KW  - Anti-adhesion therapy
UR  - https://www.sciencedirect.com/science/article/pii/S0008621516303160?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0008621516303160?via%3Dihub
N2  - The opportunistic Gram-negative bacterium Burkholderia cenocepacia causes lethal infections in cystic fibrosis patients. Multivalent mannoside derivatives were prepared as potential inhibitors of lectin BC2L-A, one of the virulence factors deployed by B. cenocepacia in the infection process. The interaction between the glycoclusters and the mannose binding BC2L-A lectin from B. cenocepacia was examined by isothermal microcalorimetry, surface plasmon resonance, inhibition of yeast agglutination and analytical ultracentrifugation.
ER  -

CSÁVÁS, Magdolna, Lenka MALINOVSKÁ, Florent PERRET, Milán GYURKÓ, Zita Tünde ILLYÉS, Michaela WIMMEROVÁ and Anikó BORBÁS. Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia. \textit{Carbohydrate Research}. Elsevier Science, 2017, vol.~437, January 2017, p.~1-8. ISSN~0008-6215. Available from: https://dx.doi.org/10.1016/j.carres.2016.11.008.

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