VÝTVAROVÁ, Eva, Radek MAREČEK, Jan FOUSEK, Ondřej STRÝČEK and Ivan REKTOR. Large-scale cortico-subcortical functional networks in focal epilepsies: The role of the basal ganglia. NeuroImage-Clinical. Oxford: Elsevier BV, vol. 2017, No 14, p. 28-36. ISSN 2213-1582. doi:10.1016/j.nicl.2016.12.014. 2017.
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Basic information
Original name Large-scale cortico-subcortical functional networks in focal epilepsies: The role of the basal ganglia
Authors VÝTVAROVÁ, Eva (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Jan FOUSEK (203 Czech Republic, belonging to the institution), Ondřej STRÝČEK (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution).
Edition NeuroImage-Clinical, Oxford, Elsevier BV, 2017, 2213-1582.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30103 Neurosciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.869
RIV identification code RIV/00216224:14740/17:00094611
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1016/j.nicl.2016.12.014
UT WoS 000405984300003
Keywords in English Functional magnetic resonance imaging; Functional connectivity; Epilepsy; Network analysis; Partial least square analysis
Tags OA, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 26/4/2018 12:49.
Abstract
Objectives: The aimwas to describe the contribution of basal ganglia (BG) thalamo-cortical circuitry to thewholebrain functional connectivity in focal epilepsies. Methods: Interictal resting-state fMRI recordings were acquired in 46 persons with focal epilepsies. Of these 46, 22 had temporal lobe epilepsy: 9 left temporal (LTLE), 13 right temporal (RTLE); 15 had frontal lobe epilepsy (FLE); and 9 had parietal/ occipital lobe epilepsy (POLE). There were 20 healthy controls. The completeweighted networkwas analyzed based on correlation matrices of 90 and 194 regions. The network topologywas quantified on a global and regional level by measures based on graph theory, and connection-level changes were analyzed by the partial least square method. Results: In all patient groups except RTLE, the shift of the functional network topology away from random was observed (normalized clustering coefficient and characteristic path length were higher in patient groups than in controls). Links contributing to this change were found in the cortico-subcortical connections. Weak connections (low correlations) consistently contributed to thismodification of the network. The importance of regions changed: decreases in the subcortical areas and both decreases and increases in the cortical areas were observed in node strength, clustering coefficient and eigenvector centrality in patient groups when compared to controls. Node strength decreases of the basal ganglia, i.e. the putamen, caudate, and pallidum, were displayed in LTLE, FLE, and POLE. The connectivity within the basal ganglia-thalamus circuitry was not disturbed; the disturbance concerned the connectivity between the circuitry and the cortex. Significance: Focal epilepsies affect large-scale brain networks beyond the epileptogenic zones. Cortico-subcortical functional connectivity disturbance was displayed in LTLE, FLE, and POLE. Significant changes in the restingstate functional connectivity between cortical and subcortical structures suggest an important role of the BG and thalamus in focal epilepsies.
Links
GAP103/11/0933, research and development projectName: Analýza vysokofrekvenčního EEG signálu z hlubokých mozkových elektrod
Investor: Czech Science Foundation
LM2010005, research and development projectName: Velká infrastruktura CESNET (Acronym: VI CESNET)
Investor: Ministry of Education, Youth and Sports of the CR
LQ1601, research and development projectName: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
MUNI/A/0897/2016, interní kód MUName: Rozsáhlé výpočetní systémy: modely, aplikace a verifikace VI.
Investor: Masaryk University, Category A
MUNI/A/0945/2015, interní kód MUName: Rozsáhlé výpočetní systémy: modely, aplikace a verifikace V.
Investor: Masaryk University, Category A
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