KOUDELKA, Adolf, Gabriela AMBROŽOVÁ, Anna KLINKE, Táňa FIDLEROVÁ, Hana VEREŠČÁKOVÁ, Radek KUCHTA, Tanja K RUDOLPH, Jaroslav KADLEC, Zdenka KUCHTOVA, Steven R. WOODCOCK, Bruce A. FREEMAN, Lukáš KUBALA and Michaela PEKAROVÁ. Nitro-Oleic Acid Prevents Hypoxia-and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction. Cardiovascular Drugs and Therapy. Springer, 2016, vol. 30, No 6, p. 579-586. ISSN 0920-3206. Available from: https://dx.doi.org/10.1007/s10557-016-6700-3.
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Basic information
Original name Nitro-Oleic Acid Prevents Hypoxia-and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction
Authors KOUDELKA, Adolf (203 Czech Republic), Gabriela AMBROŽOVÁ (203 Czech Republic), Anna KLINKE, Táňa FIDLEROVÁ (203 Czech Republic, belonging to the institution), Hana VEREŠČÁKOVÁ (203 Czech Republic, belonging to the institution), Radek KUCHTA, Tanja K RUDOLPH, Jaroslav KADLEC, Zdenka KUCHTOVA, Steven R. WOODCOCK, Bruce A. FREEMAN, Lukáš KUBALA (203 Czech Republic) and Michaela PEKAROVÁ (703 Slovakia, guarantor).
Edition Cardiovascular Drugs and Therapy, Springer, 2016, 0920-3206.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.820
RIV identification code RIV/00216224:14310/16:00114974
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1007/s10557-016-6700-3
UT WoS 000390066300005
Keywords in English Nitro-oleic acid; Asymmetric dimethylarginine; Hypoxia; Pulmonary hypertension; Human pulmonary artery endothelial cell
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Marie Šípková, DiS., učo 437722. Changed: 10/6/2020 16:02.
Abstract
Pulmonary hypertension (PH) represents a serious health complication accompanied with hypoxic conditions, elevated levels of asymmetric dimethylarginine (ADMA), and overall dysfunction of pulmonary vascular endothelium. Since the prevention strategies for treatment of PH remain largely unknown, our study aimed to explore the effect of nitro-oleic acid (OA-NO2), an exemplary nitro-fatty acid (NO2-FA), in human pulmonary artery endothelial cells (HPAEC) under the influence of hypoxia or ADMA.
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