Detailed Information on Publication Record
2015
Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin
ADAMOVSKÝ, Ondřej, Zdena MOOSOVÁ, Michaela PEKAROVÁ, Amrita BASU, Pavel BABICA et. al.Basic information
Original name
Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin
Authors
ADAMOVSKÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution), Zdena MOOSOVÁ (203 Czech Republic, belonging to the institution), Michaela PEKAROVÁ (703 Slovakia), Amrita BASU (356 India, belonging to the institution), Pavel BABICA (203 Czech Republic, belonging to the institution), Lenka ŠVIHÁLKOVÁ ŠINDLEROVÁ (203 Czech Republic), Lukáš KUBALA (203 Czech Republic) and Luděk BLÁHA (203 Czech Republic, belonging to the institution)
Edition
Environmental Science & Technology, WASHINGTON, The American Chemical Society, 2015, 0013-936X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10511 Environmental sciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 5.393
RIV identification code
RIV/00216224:14310/15:00107138
Organization unit
Faculty of Science
UT WoS
000363348700054
Keywords in English
Immunomodulatory Potency; Microcystin; Cyanobacterial Toxin
Tags
Tags
International impact, Reviewed
Změněno: 8/4/2020 14:43, Mgr. Marie Šípková, DiS.
Abstract
V originále
Microcystins (MCs) are primarily hepatotoxins produced by cyanobacteria and are responsible for intoxication in humans and animals. There are many incidents of chronic exposure to MCs, which have been attributed to the inappropriate treatment of water supplies or contaminated food. Using RAW 264.7 macrophages, we showed the potency of microcystin-LR (MC-LR) to stimulate production of pro-inflammatory cytokines (tumor necrosis factor alpha and interleukin-6) as a consequence of fast nuclear factor kappa B and nitrogen-activated protein kinase activation. In contrast to other studies, the observed effects were not attributed to the intracellular inhibition of protein phosphatases 1/2A due to lack of specific transmembrane transporters for MCs. However, the MC-LR-induced activation of macrophages was effectively inhibited by a specific peptide that blocks signaling of receptors, which play a pivotal role in the innate immune responses. Taken together, we showed for the first time that MC-LR could interfere with macrophage receptors that are responsible for triggering the above-mentioned signaling pathways. These findings provide an interesting mechanistic explanation of some adverse health outcomes associated with toxic cyanobacteria and MCs.
Links
| GP13-27695P, research and development project |
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