The Effect of Cardiac Filling on Heart Rate Variability in
Rabbit Isolated Heart

D 2017

The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart

JANOUSEK, Oto, Marina RONZHINA, Jakub HEJC, Tibor STRAČINA, Veronika OLEJNÍČKOVÁ et. al.

Basic information

Original name

The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart

Authors

JANOUSEK, Oto (203 Czech Republic), Marina RONZHINA (203 Czech Republic), Jakub HEJC (203 Czech Republic), Tibor STRAČINA (703 Slovakia, belonging to the institution), Veronika OLEJNÍČKOVÁ (203 Czech Republic, belonging to the institution) and Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution)

Edition

Washington, Computing in Cardiology 2016, p. 501-504, 4 pp. 2017

Publisher

IEEE Computer Society

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30105 Physiology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

References:

URL

RIV identification code

RIV/00216224:14110/17:00094616

Organization unit

Faculty of Medicine

ISBN

978-1-5090-0896-4

ISSN

Keywords in English

heart rate variability

Abstract

V originále

Presence of heart rate variability (HRV) in isolated hearts is widely recognized; however, its mechanisms are still subject of debate. One of the possible explanations is that mechanoreceptors in cardiac tissue affect HRV. In order to evaluate possible dependence of HRV on heart mechanoreceptors activated during left ventricle filling, the HRV parameters in two perfusion modes of isolated heart were compared: Langendorff and working heart mode. Ten New Zealand rabbit isolated hearts were perfused (Krebs-Henseleit, 37°C, 85 mmHg) in Langendorff mode and consecutively in working heart mode (8 cmH2O preload, 60 cmfyO afterload). A total of 27 HRV parameters in time, frequency, geometric, and non-linear domain were computed. No significant differences (Wilcoxon signed rank test, p < 0.05) were found among all studied HRV parameters between Langendorff and working heart mode. The study confirms the presence of heart rate fluctuation in isolated hearts in both Langendorff and working heart modes. Results of statistical analysis show that heart rate fluctuation is irrespective to mechanical stimulation of heart during atrium and ventricle filling.

Links

GAP102/12/2034, research and development project

Name: Analýza vztahu mezi elektrickými ději a průtokem krve u srdečních komor

Investor: Czech Science Foundation

MUNI/A/1365/2015, interní kód MU

Name: Kardiovaskulární systém: od modelu přes terapii k prevenci (Acronym: KAMOTEPRE)

Investor: Masaryk University, Category A

Citovat

JANOUSEK, Oto, Marina RONZHINA, Jakub HEJC, Tibor STRAČINA, Veronika OLEJNÍČKOVÁ and Marie NOVÁKOVÁ. The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart. In Alan Murray. Computing in Cardiology 2016. Washington: IEEE Computer Society, 2017, p. 501-504. ISBN 978-1-5090-0896-4.

@inproceedings{1368635,
   author = {Janousek, Oto and Ronzhina, Marina and Hejc, Jakub and Stračina, Tibor and Olejníčková, Veronika and Nováková, Marie},
   address = {Washington},
   booktitle = {Computing in Cardiology 2016},
   editor = {Alan Murray},
   keywords = {heart rate variability},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Washington},
   isbn = {978-1-5090-0896-4},
   pages = {501-504},
   publisher = {IEEE Computer Society},
   title = {The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart},
   url = {http://ieeexplore.ieee.org/document/7868789/},
   year = {2017}
}

TY  - JOUR
ID  - 1368635
AU  - Janousek, Oto - Ronzhina, Marina - Hejc, Jakub - Stračina, Tibor - Olejníčková, Veronika - Nováková, Marie
PY  - 2017
TI  - The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart
PB  - IEEE Computer Society
CY  - Washington
SN  - 9781509008964
KW  - heart rate variability
UR  - http://ieeexplore.ieee.org/document/7868789/
L2  - http://ieeexplore.ieee.org/document/7868789/
N2  - Presence of heart rate variability (HRV) in isolated hearts is widely recognized; however, its mechanisms are still subject of debate. One of the possible explanations is that mechanoreceptors in cardiac tissue affect HRV. In order to evaluate possible dependence of HRV on heart mechanoreceptors activated during left ventricle filling, the HRV parameters in two perfusion modes of isolated heart were compared: Langendorff and working heart mode. Ten New Zealand rabbit isolated hearts were perfused (Krebs-Henseleit, 37°C, 85 mmHg) in Langendorff mode and consecutively in working heart mode (8 cmH2O preload, 60 cmfyO afterload). A total of 27 HRV parameters in time, frequency, geometric, and non-linear domain were computed. No significant differences (Wilcoxon signed rank test, p < 0.05) were found among all studied HRV parameters between Langendorff and working heart mode. The study confirms the presence of heart rate fluctuation in isolated hearts in both Langendorff and working heart modes. Results of statistical analysis show that heart rate fluctuation is irrespective to mechanical stimulation of heart during atrium and ventricle filling.
ER  -

JANOUSEK, Oto, Marina RONZHINA, Jakub HEJC, Tibor STRAČINA, Veronika OLEJNÍČKOVÁ and Marie NOVÁKOVÁ. The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart. In Alan Murray. \textit{Computing in Cardiology 2016}. Washington: IEEE Computer Society, 2017, p.~501-504. ISBN~978-1-5090-0896-4.

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