Response of Ventricular Repolarization Parameters to Preload
Changes in the Isolated Working Heart

D 2017

Response of Ventricular Repolarization Parameters to Preload Changes in the Isolated Working Heart

HEJC, Jakub, Oto JANOUSEK, Marina RONZHINA, Tibor STRAČINA, Veronika OLEJNÍČKOVÁ et. al.

Basic information

Original name

Response of Ventricular Repolarization Parameters to Preload Changes in the Isolated Working Heart

Authors

HEJC, Jakub (203 Czech Republic), Oto JANOUSEK (203 Czech Republic), Marina RONZHINA (203 Czech Republic), Tibor STRAČINA (703 Slovakia, belonging to the institution), Veronika OLEJNÍČKOVÁ (203 Czech Republic, belonging to the institution), Jana KOLAROVA (203 Czech Republic) and Marie NOVÁKOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Washington, Computing in Cardiology 2016, p. 409-412, 4 pp. 2017

Publisher

IEEE Computer Society

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30105 Physiology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

RIV identification code

RIV/00216224:14110/17:00094617

Organization unit

Faculty of Medicine

ISBN

978-1-5090-0896-4

ISSN

UT WoS

000405710400103

Keywords in English

Response of Ventricular Repolarization Parameters

Abstract

V originále

Heart rate dependency of ventricular repolarization (VR) parameters has been a well known phenomenon for many years. Other contributing factors, such as Mechano-electric Coupling, are still under investigation. In this work, we analyze step response of VR parameters after abrupt change in mechanical end-diastolic load. 10 isolated rabbit hearts were perfused in Working Heart mode. The protocol consisted of abrupt changes in preload level of 3 cm/fcO. Left ventricle electric activity was recorded by seven unipolar leads at sampling frequency 10 kHz. A second-order transfer function model was used to identify basic parameters of Q.TEND and QTPEAK step responses, detected in reconstructed global pseudo-lead. Results show inverse relationship between changes in the preload and the length of QT related intervals. Increase of the preload causes significant (p<0.05) shortening of both intervals within the range of 1.6-26.9 ms. On the contrary, preload decreasing leads to prolongation of repolarization parameters, however, with significantly lower (p<0.05) average magnitude. Dynamic response is highly individual among each heart. Average time needed to reach stable QT in our data is 336.0 seconds, while min. and max. value is 41.4 and 894.0 seconds, respectively.

Links

GAP102/12/2034, research and development project

Name: Analýza vztahu mezi elektrickými ději a průtokem krve u srdečních komor

Investor: Czech Science Foundation

MUNI/A/1326/2014, interní kód MU

Name: Kardiovaskulární systém od buňky k lůžku pacienta (Acronym: KASBUNPAC)

Investor: Masaryk University, Category A

Citovat

HEJC, Jakub, Oto JANOUSEK, Marina RONZHINA, Tibor STRAČINA, Veronika OLEJNÍČKOVÁ, Jana KOLAROVA and Marie NOVÁKOVÁ. Response of Ventricular Repolarization Parameters to Preload Changes in the Isolated Working Heart. In Alan Murray. Computing in Cardiology 2016. Washington: IEEE Computer Society, 2017, p. 409-412. ISBN 978-1-5090-0896-4.

@inproceedings{1368637,
   author = {Hejc, Jakub and Janousek, Oto and Ronzhina, Marina and Stračina, Tibor and Olejníčková, Veronika and Kolarova, Jana and Nováková, Marie},
   address = {Washington},
   booktitle = {Computing in Cardiology 2016},
   editor = {Alan Murray},
   keywords = {Response of Ventricular Repolarization Parameters},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Washington},
   isbn = {978-1-5090-0896-4},
   pages = {409-412},
   publisher = {IEEE Computer Society},
   title = {Response of Ventricular Repolarization Parameters to Preload Changes in the Isolated Working Heart},
   year = {2017}
}

TY  - JOUR
ID  - 1368637
AU  - Hejc, Jakub - Janousek, Oto - Ronzhina, Marina - Stračina, Tibor - Olejníčková, Veronika - Kolarova, Jana - Nováková, Marie
PY  - 2017
TI  - Response of Ventricular Repolarization Parameters to Preload Changes in the Isolated Working Heart
PB  - IEEE Computer Society
CY  - Washington
SN  - 9781509008964
KW  - Response of Ventricular Repolarization Parameters
N2  - Heart rate dependency of ventricular repolarization (VR) parameters has been a well known phenomenon for many years. Other contributing factors, such as Mechano-electric Coupling, are still under investigation. In this work, we analyze step response of VR parameters after abrupt change in mechanical end-diastolic load. 10 isolated rabbit hearts were perfused in Working Heart mode. The protocol consisted of abrupt changes in preload level of 3 cm/fcO. Left ventricle electric activity was recorded by seven unipolar leads at sampling frequency 10 kHz. A second-order transfer function model was used to identify basic parameters of Q.TEND and QTPEAK step responses, detected in reconstructed global pseudo-lead. Results show inverse relationship between changes in the preload and the length of QT related intervals. Increase of the preload causes significant (p<0.05) shortening of both intervals within the range of 1.6-26.9 ms. On the contrary, preload decreasing leads to prolongation of repolarization parameters, however, with significantly lower (p<0.05) average magnitude. Dynamic response is highly individual among each heart. Average time needed to reach stable QT in our data is 336.0 seconds, while min. and max. value is 41.4 and 894.0 seconds, respectively.
ER  -

HEJC, Jakub, Oto JANOUSEK, Marina RONZHINA, Tibor STRAČINA, Veronika OLEJNÍČKOVÁ, Jana KOLAROVA and Marie NOVÁKOVÁ. Response of Ventricular Repolarization Parameters to Preload Changes in the Isolated Working Heart. In Alan Murray. \textit{Computing in Cardiology 2016}. Washington: IEEE Computer Society, 2017, p.~409-412. ISBN~978-1-5090-0896-4.

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