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@article{1369967,
author = {Petr, Marek and Helma, Robert and Polášková, Alena and Krejčí, Aneta and Dvořáková, Zuzana and Kejnovská, Iva and Navrátilová, Lucie and Adámik, Matej and Vorlíčková, Michaela and Brázdová, Marie and Rumíšková, Gabriela},
article_location = {London},
doi = {http://dx.doi.org/10.1042/BSR20160232},
keywords = {DNA-protein interaction; G-quadruplex; MYC; p53 protein},
language = {eng},
issn = {0144-8463},
journal = {Bioscience Reports},
title = {Wild-type p53 binds to MYC promoter G-quadruplex},
url = {http://dx.doi.org/10.1042/BSR20160232},
volume = {36},
year = {2016}
}
TY - JOUR
ID - 1369967
AU - Petr, Marek - Helma, Robert - Polášková, Alena - Krejčí, Aneta - Dvořáková, Zuzana - Kejnovská, Iva - Navrátilová, Lucie - Adámik, Matej - Vorlíčková, Michaela - Brázdová, Marie - Rumíšková, Gabriela
PY - 2016
TI - Wild-type p53 binds to MYC promoter G-quadruplex
JF - Bioscience Reports
VL - 36
PB - Portland Press LTD
SN - 01448463
KW - DNA-protein interaction
KW - G-quadruplex
KW - MYC
KW - p53 protein
UR - http://dx.doi.org/10.1042/BSR20160232
L2 - http://dx.doi.org/10.1042/BSR20160232
N2 - G-quadruplexes are four-stranded nucleic acid structures that are implicated in the regulation of transcription, translation and replication. Genome regions enriched in putative G-quadruplex motifs include telomeres and gene promoters. Tumour suppressor p53 plays a critical role in regulatory pathways leading to cell cycle arrest, DNA repair and apoptosis. In addition to transcriptional regulation mediated via sequence-specific DNA binding, p53 can selectively bind various non-B DNA structures. In the present study, wild-type p53 (wtp53) binding to G-quadruplex formed by MYC promoter nuclease hypersensitive element (NHE) III1 region was investigated. Wtp53 binding to MYC G-quadruplex is comparable to interaction with specific p53 consensus sequence (p53CON). Apart from the full-length wtp53, its isolated C-terminal region (aa 320-393) as well, is capable of high-affinity MYC G-quadruplex binding, suggesting its critical role in this type of interaction. Moreover, wtp53 binds to MYC promoter region containing putative G-quadruplex motif in two wtp53-expressing cell lines. The results suggest that wtp53 binding to G-quadruplexes can take part in transcriptional regulation of its target genes.
ER -
PETR, Marek, Robert HELMA, Alena POLÁŠKOVÁ, Aneta KREJČÍ, Zuzana DVOŘÁKOVÁ, Iva KEJNOVSKÁ, Lucie NAVRÁTILOVÁ, Matej ADÁMIK, Michaela VORLÍČKOVÁ, Marie BRÁZDOVÁ and Gabriela RUMÍŠKOVÁ. Wild-type p53 binds to MYC promoter G-quadruplex. \textit{Bioscience Reports}. London: Portland Press LTD, vol.~36, 11 pp. ISSN~0144-8463. doi:10.1042/BSR20160232. 2016.
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