| PENKA, Igor, Zdeněk KALA, Andrea ZETELOVÁ, Lumír KUNOVSKÝ, Petr SZTURZ, Leoš KŘEN, Marek MECHL, Z. REHAK and Ivo HANKE. Castleman's disease - surgical treatment, case reports. Rozhledy v chirurgii. Praha: Česká lékařská společnost J.E.Purkyně, 2016, vol. 95, No 12, p. 458-461. ISSN 0035-9351. |
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@article{1370715,
author = {Penka, Igor and Kala, Zdeněk and Zetelová, Andrea and Kunovský, Lumír and Szturz, Petr and Křen, Leoš and Mechl, Marek and Rehak, Z. and Hanke, Ivo},
article_location = {Praha},
article_number = {12},
keywords = {Castleman's disease; lymphoproliferation; lymphadenopathy; surgical treatment},
language = {eng},
issn = {0035-9351},
journal = {Rozhledy v chirurgii},
title = {Castleman's disease - surgical treatment, case reports},
volume = {95},
year = {2016}
}
TY - JOUR
ID - 1370715
AU - Penka, Igor - Kala, Zdeněk - Zetelová, Andrea - Kunovský, Lumír - Szturz, Petr - Křen, Leoš - Mechl, Marek - Rehak, Z. - Hanke, Ivo
PY - 2016
TI - Castleman's disease - surgical treatment, case reports
JF - Rozhledy v chirurgii
VL - 95
IS - 12
SP - 458-461
EP - 458-461
PB - Česká lékařská společnost J.E.Purkyně
SN - 00359351
KW - Castleman's disease
KW - lymphoproliferation
KW - lymphadenopathy
KW - surgical treatment
N2 - The authors describe their experience with surgical treatment of benign rare lymph proliferation - Castleman's disease (CD). It occurs in unicentric and multicentric forms. The very low incidence of the disease makes it very difficult to design larger prospective studies. Cases of two leading localizations of the unicentric form of CD - intrathoracic and retroperitoneal with special emphasis on the preoperative diagnosis and imaging options are described. This article underlines the curative potential of surgical treatment where a complete resection of the affected lymph node leads to eradication in almost 100% of the cases. The discussion is focused on the forms of CD - different localization, clinical symptoms and course of disease. It discusses the differential diagnosis, particularly difficult in the multicentric form, emphasizing the need to exclude malignant lympho-ma.The etiopathogenesis of the disease is presented, mentioning its association with HIV (Human Immunodeficiency Virus) infection and HHV-8 (Human herpers virus 8) infection and the importance of overproduction of proinflammatory cytokines. The importance of surgical therapy for the unicentric form of CD is highlighted as compared to the multicentric form, where the surgeon's task involves taking a biopsy-required for an accurate diagnosis.
ER -
PENKA, Igor, Zdeněk KALA, Andrea ZETELOVÁ, Lumír KUNOVSKÝ, Petr SZTURZ, Leoš KŘEN, Marek MECHL, Z. REHAK and Ivo HANKE. Castleman's disease - surgical treatment, case reports. \textit{Rozhledy v chirurgii}. Praha: Česká lékařská společnost J.E.Purkyně, 2016, vol.~95, No~12, p.~458-461. ISSN~0035-9351.
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