HASSAN, Walid Fathalla M., Ibrahim A. I. ALI and Pavel PAZDERA. A novel method for heterocyclic amide–thioamide transformations. Beilstein Journal of Organic Chemistry. vol. 13, June, p. 174-181. ISSN 1860-5397. doi:10.3762/bjoc.13.20. 2017.
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Basic information
Original name A novel method for heterocyclic amide–thioamide transformations
Authors HASSAN, Walid Fathalla M. (818 Egypt, belonging to the institution), Ibrahim A. I. ALI (818 Egypt) and Pavel PAZDERA (203 Czech Republic, guarantor, belonging to the institution).
Edition Beilstein Journal of Organic Chemistry, 2017, 1860-5397.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10401 Organic chemistry
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.330
RIV identification code RIV/00216224:14310/17:00096105
Organization unit Faculty of Science
Doi http://dx.doi.org/10.3762/bjoc.13.20
UT WoS 000395042800001
Keywords in English heterocyclic amides; heterocyclic thioamides; N-cyclohexyl dithiocarbamate cyclohexylammonium salt; novel thiating agent; thiation
Tags NZ, rivok
Changed by Changed by: Ing. Nicole Zrilić, učo 240776. Changed: 27/3/2018 16:16.
Abstract
In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61 °C to afford heteocyclic thioamides in excellent yields.
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