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@article{1371691,
author = {Valkova, V. and Jircikova, J. and Trnkova, M. and Steinerova, K. and Keslova, P. and Lanska, M. and Koristek, Z. and Raida, L. and Krejčí, Marta and Kruntoradova, K. and Dolezal, T. and Benesova, K. and Cetkovsky, P. and Trneny, M.},
article_location = {Bratislava},
article_number = {5},
doi = {http://dx.doi.org/10.4149/neo_2016_511},
keywords = {QOL; allogeneic; transplantation; FACT-G},
language = {eng},
issn = {0028-2685},
journal = {Neoplasma},
title = {The quality of life following allogeneic hematopoietic stem cell transplantation - a multicenter retrospective study},
volume = {63},
year = {2016}
}
TY - JOUR
ID - 1371691
AU - Valkova, V. - Jircikova, J. - Trnkova, M. - Steinerova, K. - Keslova, P. - Lanska, M. - Koristek, Z. - Raida, L. - Krejčí, Marta - Kruntoradova, K. - Dolezal, T. - Benesova, K. - Cetkovsky, P. - Trneny, M.
PY - 2016
TI - The quality of life following allogeneic hematopoietic stem cell transplantation - a multicenter retrospective study
JF - Neoplasma
VL - 63
IS - 5
SP - 743-751
EP - 743-751
PB - Slovenská akademie vied
SN - 00282685
KW - QOL
KW - allogeneic
KW - transplantation
KW - FACT-G
N2 - Although allogeneic haematopoietic stem cell transplantation (allo-HSCT) offers a unique curative potential, it may be connected with high treatment-related morbidity and mortality. Besides many organ complications, allo-HSCT may significantly affect quality of life (QOL). Patients and methods: Between January 2011 and December 2012, five hundred and ninety patients (pts) from 6 transplant centers in the Czech Republic filled in the questionnaire for the quantitative measurement of QOL using Functional Assessment of Cancer Therapy-General (FACT-G) version 4. Study cohort characteristics were as follows: 325 males, 340 pts received myeloablative conditioning, 383 pts received PBPC, representation of diagnoses; acute leukemia (n=270), bone marrow failure (n=36), chronic myeloid leukemia (n=74), myelodysplastic/myeloproliferative syndrom (n=110), lymphoproliferative disease (n=93). The median age at allo-HSCT was 43 years (range: 1.7 - 71.0), the median time from allo-HSCT to questionnaire completing was 3.8 years (range:- 0.2 - 21.6). The earliest allo-HSCT was performed in November 1989, the last in September 2012. In this retrospective study, we investigated the impact of various factors on the QOL after allo-HSCT: age, gender, diagnosis, type of conditioning, time from diagnosis to allo-HSCT, disease stage, graft type, donor type, time from allo-HSCT to questionnaire completing, GVHD, relapse. Only data from patients who were more than 3 months after allo-HSCT were used for the multivariate analysis. The overall results of the total FACT-G score (median=85.0; range: 29-108) as well as the results of each specific dimension - PWB (median=23.0; range: 5-28), SWB (median=24.0; range: 7-28), EWB (median=19.0; range: 4-24), FWB (mean=21.0; range: 2-28) showed a value in the highest quartile of the possible evaluation. In multivariate analysis, an inferior QOL score was reported for patients with aGVHD (p=0.002), cGVHD (p<0.001), QOL decreased with increasing age (p=0.048) and increased with time elapsed since allo-HSCT (p<0.001). Allogeneic HSCT represents an important intervention into the overall integrity of the organism. In particular, the development of GVHD can cause very serious organ, but also mental problems which can significantly reduce the QOL. The QOL is steadily increasing with increasing interval from allo-HSCT but improvement and disappearance of these complications may take many years, and sometimes these effects may probably persist permanently.
ER -
VALKOVA, V., J. JIRCIKOVA, M. TRNKOVA, K. STEINEROVA, P. KESLOVA, M. LANSKA, Z. KORISTEK, L. RAIDA, Marta KREJČÍ, K. KRUNTORADOVA, T. DOLEZAL, K. BENESOVA, P. CETKOVSKY a M. TRNENY. The quality of life following allogeneic hematopoietic stem cell transplantation - a multicenter retrospective study. Online. \textit{Neoplasma}. Bratislava: Slovenská akademie vied, 2016, roč.~63, č.~5, s.~743-751. ISSN~0028-2685. Dostupné z: https://dx.doi.org/10.4149/neo\_{}2016\_{}511. [citováno 2024-04-23]
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