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@article{1371982,
author = {Lebedová, Jana and Bláhová, Lucie and Vecera, Z. and Mikuska, P. and Docekal, B. and Buchtova, M. and Misek, I. and Dumková, Jana and Hampl, Aleš and Hilscherová, Klára},
article_location = {Landsberg, Germany},
article_number = {23},
doi = {http://dx.doi.org/10.1007/s11356-016-7600-6},
keywords = {Nanoparticle; Cadmium; Accumulation; Tissue damage; Lipid peroxidation; Glutathione; Oxidative stress},
language = {eng},
issn = {0944-1344},
journal = {Environmental Science and Pollution Research},
title = {Impact of acute and chronic inhalation exposure to CdO nanoparticles on mice},
url = {http://link.springer.com/article/10.1007%2Fs11356-016-7600-6},
volume = {23},
year = {2016}
}
TY - JOUR
ID - 1371982
AU - Lebedová, Jana - Bláhová, Lucie - Vecera, Z. - Mikuska, P. - Docekal, B. - Buchtova, M. - Misek, I. - Dumková, Jana - Hampl, Aleš - Hilscherová, Klára
PY - 2016
TI - Impact of acute and chronic inhalation exposure to CdO nanoparticles on mice
JF - Environmental Science and Pollution Research
VL - 23
IS - 23
SP - 24047-24060
EP - 24047-24060
PB - Ecomed
SN - 09441344
KW - Nanoparticle
KW - Cadmium
KW - Accumulation
KW - Tissue damage
KW - Lipid peroxidation
KW - Glutathione
KW - Oxidative stress
UR - http://link.springer.com/article/10.1007%2Fs11356-016-7600-6
L2 - http://link.springer.com/article/10.1007%2Fs11356-016-7600-6
N2 - Cadmium nanoparticles can represent a risk in both industrial and environmental settings, but there is little knowledge on the impacts of their inhalation, especially concerning longer-term exposures. In this study, mice were exposed to cadmium oxide (CdO) nanoparticles in whole body inhalation chambers for 4 to 72 h in acute and 1 to 13 weeks (24 h/day, 7 days/week) in chronic exposure to investigate the dynamics of nanoparticle uptake and effects. In the acute experiment, mice were exposed to 2.95 x 10(6) particles/cm(3) (31.7 mu g CdO/m(3)). The same concentration and a lower one (1.18 x 10(6) particles/cm(3), 12.7 mu g CdO/m(3)) were used for the chronic exposure. Transmission electron microscopy documented distribution of nanoparticles into all studied organs. Major portion of nanoparticles was retained in the lung, but longer exposure led to a greater relative redistribution into secondary organs, namely the kidney, and also the liver and spleen. Accumulation of Cd in the lung and liver occurred already after 24 h and in the brain, kidney, and spleen after 72 h of exposure, and a further increase of Cd levels was observed throughout the chronic exposure. There were significant differences in both Cd accumulation and effects between the two exposure doses. Lung weight in the higher exposure group increased up to 2-fold compared to the control. Histological analyses showed dose-dependent alterations in lung and liver morphology and damage to their tissue. Modulation of oxidative stress parameters including glutathione levels and increased lipid peroxidation occurred mainly after the greater chronic exposure. The results emphasize risk of longer-term inhalation of cadmium nanoparticles, since adverse effects occurring after shorter exposures gradually progressed with a longer exposure duration.
ER -
LEBEDOVÁ, Jana, Lucie BLÁHOVÁ, Z. VECERA, P. MIKUSKA, B. DOCEKAL, M. BUCHTOVA, I. MISEK, Jana DUMKOVÁ, Aleš HAMPL and Klára HILSCHEROVÁ. Impact of acute and chronic inhalation exposure to CdO nanoparticles on mice. \textit{Environmental Science and Pollution Research}. Landsberg, Germany: Ecomed, 2016, vol.~23, No~23, p.~24047-24060. ISSN~0944-1344. Available from: https://dx.doi.org/10.1007/s11356-016-7600-6.
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