Impact of untreated wastewater on a major European river
evaluated with a combination of in vitro bioassays and chemical
analysis

J 2017

Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis

KONIG, Maria, Beate I. ESCHER, Peta A. NEALE, Martin KRAUSS, Klára HILSCHEROVÁ et. al.

Basic information

Original name

Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis

Authors

KONIG, Maria (276 Germany), Beate I. ESCHER (276 Germany, guarantor), Peta A. NEALE (36 Australia), Martin KRAUSS (276 Germany), Klára HILSCHEROVÁ (203 Czech Republic, belonging to the institution), Jiří NOVÁK (203 Czech Republic, belonging to the institution), Ivana TEODOROVIC (688 Serbia), Tobias SCHULZE (276 Germany), Sven SEIDENSTICKER (276 Germany), Muhammad Arslan Kamal HASHMI (276 Germany), Joerg AHLHEIM (276 Germany) and Werner BRACK (276 Germany)

Edition

Environmental Pollution, OXFORD, ELSEVIER SCI LTD, 2017, 0269-7491

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.358

RIV identification code

RIV/00216224:14310/17:00096131

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.envpol.2016.11.011

UT WoS

000390732300050

Keywords in English

Bioassay; Xenobiotic metabolism; Specific modes of action; Adaptive stress response; Bioanalytical equivalent concentration

Abstract

V originále

Complex mixtures of micropollutants, including pesticides, pharmaceuticals and industrial chemicals emitted by wastewater effluents to European rivers may compromise the quality of these water resources and may pose a risk to ecosystem health and abstraction of drinking water. In the present study, an integrated analytical and bioanalytical approach was applied to investigate the impact of untreated wastewater effluents from the city of Novi Sad, Serbia, into the River Danube. The study was based on three on-site large volume solid phase extracted water samples collected upstream and downstream of the untreated wastewater discharge. Chemical screening with liquid chromatography high resolution mass spectrometry (LC-HRMS) was applied together with a battery of in vitro cell-based bioassays covering important steps of the cellular toxicity pathway to evaluate effects on the activation of metabolism (arylhydrocarbon receptor AhR, peroxisome proliferator activated receptor gamma PPAR gamma), specific modes of action (estrogen receptor ER alpha, androgen receptor AR) and adaptive stress responses (oxidative stress, inflammation). Increased effects, significantly changed contamination patterns and higher chemical concentrations were observed downstream of the wastewater discharge. A mass balance approach showed that enhanced endocrine disruption was in good agreement with concentrations of detected hormones, while only a smaller fraction of the effects on xenobiotic metabolism (<1%) and adaptive stress responses (0-12%) could be explained by the detected chemicals. The chemical and effects patterns observed upstream of the discharge point were fairly re-established at about 7 km downstream, demonstrating the enormous dilution capacity of this large river.

Links

603437, interní kód MU

Name: SOLUTIONS - Solutions for present and future emerging pollutants in land and water resources management (Acronym: SOLUTIONS)

Investor: European Union, Cooperation

Citovat

KONIG, Maria, Beate I. ESCHER, Peta A. NEALE, Martin KRAUSS, Klára HILSCHEROVÁ, Jiří NOVÁK, Ivana TEODOROVIC, Tobias SCHULZE, Sven SEIDENSTICKER, Muhammad Arslan Kamal HASHMI, Joerg AHLHEIM and Werner BRACK. Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis. Environmental Pollution. OXFORD: ELSEVIER SCI LTD, 2017, vol. 220, January, p. 1220-1230. ISSN 0269-7491. Available from: https://dx.doi.org/10.1016/j.envpol.2016.11.011.

@article{1371983,
   author = {Konig, Maria and Escher, Beate I. and Neale, Peta A. and Krauss, Martin and Hilscherová, Klára and Novák, Jiří and Teodorovic, Ivana and Schulze, Tobias and Seidensticker, Sven and Hashmi, Muhammad Arslan Kamal and Ahlheim, Joerg and Brack, Werner},
   article_location = {OXFORD},
   article_number = {January},
   doi = {http://dx.doi.org/10.1016/j.envpol.2016.11.011},
   keywords = {Bioassay; Xenobiotic metabolism; Specific modes of action; Adaptive stress response; Bioanalytical equivalent concentration},
   language = {eng},
   issn = {0269-7491},
   journal = {Environmental Pollution},
   title = {Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis},
   url = {http://www.sciencedirect.com/science/article/pii/S0269749116307758},
   volume = {220},
   year = {2017}
}

TY  - JOUR
ID  - 1371983
AU  - Konig, Maria - Escher, Beate I. - Neale, Peta A. - Krauss, Martin - Hilscherová, Klára - Novák, Jiří - Teodorovic, Ivana - Schulze, Tobias - Seidensticker, Sven - Hashmi, Muhammad Arslan Kamal - Ahlheim, Joerg - Brack, Werner
PY  - 2017
TI  - Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis
JF  - Environmental Pollution
VL  - 220
IS  - January
SP  - 1220-1230
EP  - 1220-1230
PB  - ELSEVIER SCI LTD
SN  - 02697491
KW  - Bioassay
KW  - Xenobiotic metabolism
KW  - Specific modes of action
KW  - Adaptive stress response
KW  - Bioanalytical equivalent concentration
UR  - http://www.sciencedirect.com/science/article/pii/S0269749116307758
L2  - http://www.sciencedirect.com/science/article/pii/S0269749116307758
N2  - Complex mixtures of micropollutants, including pesticides, pharmaceuticals and industrial chemicals emitted by wastewater effluents to European rivers may compromise the quality of these water resources and may pose a risk to ecosystem health and abstraction of drinking water. In the present study, an integrated analytical and bioanalytical approach was applied to investigate the impact of untreated wastewater effluents from the city of Novi Sad, Serbia, into the River Danube. The study was based on three on-site large volume solid phase extracted water samples collected upstream and downstream of the untreated wastewater discharge. Chemical screening with liquid chromatography high resolution mass spectrometry (LC-HRMS) was applied together with a battery of in vitro cell-based bioassays covering important steps of the cellular toxicity pathway to evaluate effects on the activation of metabolism (arylhydrocarbon receptor AhR, peroxisome proliferator activated receptor gamma PPAR gamma), specific modes of action (estrogen receptor ER alpha, androgen receptor AR) and adaptive stress responses (oxidative stress, inflammation). Increased effects, significantly changed contamination patterns and higher chemical concentrations were observed downstream of the wastewater discharge. A mass balance approach showed that enhanced endocrine disruption was in good agreement with concentrations of detected hormones, while only a smaller fraction of the effects on xenobiotic metabolism (<1%) and adaptive stress responses (0-12%) could be explained by the detected chemicals. The chemical and effects patterns observed upstream of the discharge point were fairly re-established at about 7 km downstream, demonstrating the enormous dilution capacity of this large river.
ER  -

KONIG, Maria, Beate I. ESCHER, Peta A. NEALE, Martin KRAUSS, Klára HILSCHEROVÁ, Jiří NOVÁK, Ivana TEODOROVIC, Tobias SCHULZE, Sven SEIDENSTICKER, Muhammad Arslan Kamal HASHMI, Joerg AHLHEIM and Werner BRACK. Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis. \textit{Environmental Pollution}. OXFORD: ELSEVIER SCI LTD, 2017, vol.~220, January, p.~1220-1230. ISSN~0269-7491. Available from: https://dx.doi.org/10.1016/j.envpol.2016.11.011.

Detailed Information on Publication Record