| ZDRAŽILOVÁ DUBSKÁ, Lenka, Lenka FĚDOROVÁ, Kateřina PILÁTOVÁ, Peter MÚDRY, Eva HLAVÁČKOVÁ, Eva MATOULKOVÁ, Lucie FLAJŠAROVÁ, Regina DEMLOVÁ, Dalibor VALÍK a Jaroslav ŠTĚRBA. 18PTKI pazopanib impaires immunostimulatory properties of monocytes: Implication for monocyte-derived DC-based anti-cancer vaccine preparation. 2016. ISSN 0923-7534. Dostupné z: https://dx.doi.org/10.1093/annonc/mdw525.18. |
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@proceedings{1372330,
author = {Zdražilová Dubská, Lenka and Fědorová, Lenka and Pilátová, Kateřina and Múdry, Peter and Hlaváčková, Eva and Matoulková, Eva and Flajšarová, Lucie and Demlová, Regina and Valík, Dalibor and Štěrba, Jaroslav},
doi = {http://dx.doi.org/10.1093/annonc/mdw525.18},
keywords = {cancer monocytes vaccines protein-tyrosine kinase inhibitor pazopanib},
language = {eng},
title = {18PTKI pazopanib impaires immunostimulatory properties of monocytes: Implication for monocyte-derived DC-based anti-cancer vaccine preparation},
url = {https://www.annalsofoncology.org/article/S0923-7534(19)55184-5/fulltext#%20},
year = {2016}
}
TY - CONF
ID - 1372330
AU - Zdražilová Dubská, Lenka - Fědorová, Lenka - Pilátová, Kateřina - Múdry, Peter - Hlaváčková, Eva - Matoulková, Eva - Flajšarová, Lucie - Demlová, Regina - Valík, Dalibor - Štěrba, Jaroslav
PY - 2016
TI - 18PTKI pazopanib impaires immunostimulatory properties of monocytes: Implication for monocyte-derived DC-based anti-cancer vaccine preparation
KW - cancer monocytes vaccines protein-tyrosine kinase inhibitor pazopanib
UR - https://www.annalsofoncology.org/article/S0923-7534(19)55184-5/fulltext#%20
N2 - We manufacture fully personalized monocyte-derived dendritic cell-based vaccines that are evaluated in investigator-initiated clinical trial „Combined antitumor therapy with ex vivo manipulated dendritic cells producing interleukin-12 in children, adolescents and young adults with progressive, recurrent of primarily metastatic high-risk tumours”. Immunobiological part of quality control (QC) of DC batches revealed variability in immunostimulatory properties. We analyzed DC parametres within the context of patients medical history and explore the effect of anti-cancer compound on monocyte functional properties.
ER -
ZDRAŽILOVÁ DUBSKÁ, Lenka, Lenka FĚDOROVÁ, Kateřina PILÁTOVÁ, Peter MÚDRY, Eva HLAVÁČKOVÁ, Eva MATOULKOVÁ, Lucie FLAJŠAROVÁ, Regina DEMLOVÁ, Dalibor VALÍK a Jaroslav ŠTĚRBA. \textit{18PTKI pazopanib impaires immunostimulatory properties of monocytes: Implication for monocyte-derived DC-based anti-cancer vaccine preparation}. 2016. ISSN~0923-7534. Dostupné z: https://dx.doi.org/10.1093/annonc/mdw525.18.
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