Bioassay battery interlaboratory investigation of emerging
contaminants in spiked water extracts - Towards the
implementation of bioanalytical monitoring tools in water
quality assessment and monitoring

J 2016

Bioassay battery interlaboratory investigation of emerging contaminants in spiked water extracts - Towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring

DI PAOLO, Carolina, Richard OTTERMANNS, Steffen KEITER, Selim AIT-AISSA, Kerstin BLUHM et. al.

Basic information

Original name

Bioassay battery interlaboratory investigation of emerging contaminants in spiked water extracts - Towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring

Authors

DI PAOLO, Carolina (276 Germany), Richard OTTERMANNS (276 Germany), Steffen KEITER (276 Germany), Selim AIT-AISSA (250 France), Kerstin BLUHM (276 Germany), Werner BRACK (276 Germany), Magnus BREITHOLTZ (752 Sweden), Sebastian BUCHINGER (276 Germany), Mario CARERE (380 Italy), Carole CHALON (56 Belgium), Xavier COUSIN (250 France), Valeria DULIO (250 France), Beate I. ESCHER (276 Germany), Timo HAMERS (528 Netherlands), Klára HILSCHEROVÁ (203 Czech Republic, guarantor, belonging to the institution), Sergio JARQUE ORTIZ (724 Spain, belonging to the institution), Adam JONÁŠ (203 Czech Republic, belonging to the institution), Emmanuelle MAILLOT-MARECHAL (250 France), Yves MARNEFFE (56 Belgium), Mai Thao NGUYEN (528 Netherlands), Pascal PANDARD (250 France), Andrea SCHIFFERLI (756 Switzerland), Tobias SCHULZE (276 Germany), Sven SEIDENSTICKER (276 Germany), Thomas-Benjamin SEILER (276 Germany), Janet TANG (36 Australia), Ron VAN DER OOST (528 Netherlands), Etienne VERMEIRSSEN (756 Switzerland), Radka ZOUNKOVÁ (203 Czech Republic, belonging to the institution), Nick ZWART (528 Netherlands) and Henner HOLLERT (276 Germany)

Edition

Water Research, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2016, 0043-1354

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.942

RIV identification code

RIV/00216224:14310/16:00093522

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.watres.2016.08.018

UT WoS

000386401900049

Keywords in English

Triclosan; Acridine; 17 alpha-ethinylestradiol; 3-Nitrobenzanthrone; Organism-level toxicity; Mechanism-specific toxicity

Abstract

V originále

Bioassays are particularly useful tools to link the chemical and ecological assessments in water quality monitoring. Different methods cover a broad range of toxicity mechanisms in diverse organisms, and account for risks posed by non-target compounds and mixtures. There is a need to address bioassay suitability to evaluate water samples containing emerging pollutants, which are a current priority in water quality monitoring. The presented interlaboratory study (ILS) verified whether a battery of miniaturized bioassays, conducted in 11 different laboratories following their own protocols, would produce comparable results when applied to evaluate blinded samples consisting of a pristine water extract spiked with four emerging pollutants as single chemicals or mixtures, i.e. triclosan, acridine, 17 alpha-ethinylestradiol (EE2) and 3-nitrobenzanthrone (3-NBA). Assays evaluated effects on aquatic organisms from three different trophic levels and mechanism-specific effects using in vitro estrogenicity and mutagenicity assays. The test battery presented complementary sensitivity and specificity to evaluate the different blinded water extract spikes. Estrogenicity and mutagenicity assays identified with high precision the respective mechanism-specific effects of spikes even when non-specific toxicity occurred in mixture. Differences in experimental protocols, model organisms, and data analysis can be sources of variation, indicating that respective harmonized standard procedures should be followed when implementing bioassays in water monitoring. Together with other ongoing activities for the validation of a basic bioassay battery, the present study is an important step towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring.

Links

603437, interní kód MU

Name: SOLUTIONS - Solutions for present and future emerging pollutants in land and water resources management (Acronym: SOLUTIONS)

Investor: European Union, Cooperation

Citovat

DI PAOLO, Carolina, Richard OTTERMANNS, Steffen KEITER, Selim AIT-AISSA, Kerstin BLUHM, Werner BRACK, Magnus BREITHOLTZ, Sebastian BUCHINGER, Mario CARERE, Carole CHALON, Xavier COUSIN, Valeria DULIO, Beate I. ESCHER, Timo HAMERS, Klára HILSCHEROVÁ, Sergio JARQUE ORTIZ, Adam JONÁŠ, Emmanuelle MAILLOT-MARECHAL, Yves MARNEFFE, Mai Thao NGUYEN, Pascal PANDARD, Andrea SCHIFFERLI, Tobias SCHULZE, Sven SEIDENSTICKER, Thomas-Benjamin SEILER, Janet TANG, Ron VAN DER OOST, Etienne VERMEIRSSEN, Radka ZOUNKOVÁ, Nick ZWART and Henner HOLLERT. Bioassay battery interlaboratory investigation of emerging contaminants in spiked water extracts - Towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring. Water Research. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2016, vol. 104, November, p. 473-484. ISSN 0043-1354. Available from: https://dx.doi.org/10.1016/j.watres.2016.08.018.

@article{1372453,
   author = {Di Paolo, Carolina and Ottermanns, Richard and Keiter, Steffen and AitandAissa, Selim and Bluhm, Kerstin and Brack, Werner and Breitholtz, Magnus and Buchinger, Sebastian and Carere, Mario and Chalon, Carole and Cousin, Xavier and Dulio, Valeria and Escher, Beate I. and Hamers, Timo and Hilscherová, Klára and Jarque Ortiz, Sergio and Jonáš, Adam and MaillotandMarechal, Emmanuelle and Marneffe, Yves and Nguyen, Mai Thao and Pandard, Pascal and Schifferli, Andrea and Schulze, Tobias and Seidensticker, Sven and Seiler, ThomasandBenjamin and Tang, Janet and van der Oost, Ron and Vermeirssen, Etienne and Zounková, Radka and Zwart, Nick and Hollert, Henner},
   article_location = {OXFORD},
   article_number = {November},
   doi = {http://dx.doi.org/10.1016/j.watres.2016.08.018},
   keywords = {Triclosan; Acridine; 17 alpha-ethinylestradiol; 3-Nitrobenzanthrone; Organism-level toxicity; Mechanism-specific toxicity},
   language = {eng},
   issn = {0043-1354},
   journal = {Water Research},
   title = {Bioassay battery interlaboratory investigation of emerging contaminants in spiked water extracts - Towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring},
   url = {http://www.sciencedirect.com/science/article/pii/S0043135416306182},
   volume = {104},
   year = {2016}
}

TY  - JOUR
ID  - 1372453
AU  - Di Paolo, Carolina - Ottermanns, Richard - Keiter, Steffen - Ait-Aissa, Selim - Bluhm, Kerstin - Brack, Werner - Breitholtz, Magnus - Buchinger, Sebastian - Carere, Mario - Chalon, Carole - Cousin, Xavier - Dulio, Valeria - Escher, Beate I. - Hamers, Timo - Hilscherová, Klára - Jarque Ortiz, Sergio - Jonáš, Adam - Maillot-Marechal, Emmanuelle - Marneffe, Yves - Nguyen, Mai Thao - Pandard, Pascal - Schifferli, Andrea - Schulze, Tobias - Seidensticker, Sven - Seiler, Thomas-Benjamin - Tang, Janet - van der Oost, Ron - Vermeirssen, Etienne - Zounková, Radka - Zwart, Nick - Hollert, Henner
PY  - 2016
TI  - Bioassay battery interlaboratory investigation of emerging contaminants in spiked water extracts - Towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring
JF  - Water Research
VL  - 104
IS  - November
SP  - 473-484
EP  - 473-484
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 00431354
KW  - Triclosan
KW  - Acridine
KW  - 17 alpha-ethinylestradiol
KW  - 3-Nitrobenzanthrone
KW  - Organism-level toxicity
KW  - Mechanism-specific toxicity
UR  - http://www.sciencedirect.com/science/article/pii/S0043135416306182
L2  - http://www.sciencedirect.com/science/article/pii/S0043135416306182
N2  - Bioassays are particularly useful tools to link the chemical and ecological assessments in water quality monitoring. Different methods cover a broad range of toxicity mechanisms in diverse organisms, and account for risks posed by non-target compounds and mixtures. There is a need to address bioassay suitability to evaluate water samples containing emerging pollutants, which are a current priority in water quality monitoring. The presented interlaboratory study (ILS) verified whether a battery of miniaturized bioassays, conducted in 11 different laboratories following their own protocols, would produce comparable results when applied to evaluate blinded samples consisting of a pristine water extract spiked with four emerging pollutants as single chemicals or mixtures, i.e. triclosan, acridine, 17 alpha-ethinylestradiol (EE2) and 3-nitrobenzanthrone (3-NBA). Assays evaluated effects on aquatic organisms from three different trophic levels and mechanism-specific effects using in vitro estrogenicity and mutagenicity assays. The test battery presented complementary sensitivity and specificity to evaluate the different blinded water extract spikes. Estrogenicity and mutagenicity assays identified with high precision the respective mechanism-specific effects of spikes even when non-specific toxicity occurred in mixture. Differences in experimental protocols, model organisms, and data analysis can be sources of variation, indicating that respective harmonized standard procedures should be followed when implementing bioassays in water monitoring. Together with other ongoing activities for the validation of a basic bioassay battery, the present study is an important step towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring.
ER  -

DI PAOLO, Carolina, Richard OTTERMANNS, Steffen KEITER, Selim AIT-AISSA, Kerstin BLUHM, Werner BRACK, Magnus BREITHOLTZ, Sebastian BUCHINGER, Mario CARERE, Carole CHALON, Xavier COUSIN, Valeria DULIO, Beate I. ESCHER, Timo HAMERS, Klára HILSCHEROVÁ, Sergio JARQUE ORTIZ, Adam JONÁŠ, Emmanuelle MAILLOT-MARECHAL, Yves MARNEFFE, Mai Thao NGUYEN, Pascal PANDARD, Andrea SCHIFFERLI, Tobias SCHULZE, Sven SEIDENSTICKER, Thomas-Benjamin SEILER, Janet TANG, Ron VAN DER OOST, Etienne VERMEIRSSEN, Radka ZOUNKOVÁ, Nick ZWART and Henner HOLLERT. Bioassay battery interlaboratory investigation of emerging contaminants in spiked water extracts - Towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring. \textit{Water Research}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2016, vol.~104, November, p.~473-484. ISSN~0043-1354. Available from: https://dx.doi.org/10.1016/j.watres.2016.08.018.

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