First inter-laboratory comparison exercise for the
determination of anticancer drugs in aqueous samples

J 2016

First inter-laboratory comparison exercise for the determination of anticancer drugs in aqueous samples

HEATH, Ester, Marjeta CESEN, Noelia NEGREIRA, Miren Lopez DE ALDA, Laura FERRANDO-CLIMENT et. al.

Basic information

Original name

First inter-laboratory comparison exercise for the determination of anticancer drugs in aqueous samples

Authors

HEATH, Ester (705 Slovenia), Marjeta CESEN (705 Slovenia), Noelia NEGREIRA (724 Spain), Miren Lopez DE ALDA (724 Spain), Laura FERRANDO-CLIMENT (724 Spain), Lucie BLÁHOVÁ (203 Czech Republic, guarantor, belonging to the institution), Tung Viet NGUYEN (702 Singapore), Mohamed ADAHCHOUR (528 Netherlands), Achim RUEBEL (276 Germany), Neville LLEWELLYN (826 United Kingdom of Great Britain and Northern Ireland), Janez SCANCAR (705 Slovenia), Srdjan NOVAKOVIC (705 Slovenia), Vesna MISLEJ (705 Slovenia), Marjeta STRAZAR (705 Slovenia), Damia BARCELO (724 Spain) and Tina KOSJEK (705 Slovenia)

Edition

Environmental Science and Pollution Research, Landsberg, Germany, Ecomed, 2016, 0944-1344

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.741

RIV identification code

RIV/00216224:14310/16:00093523

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1007/s11356-015-4982-9

UT WoS

000380369900002

Keywords in English

Inter-laboratory study; Cytostatic; Pharmaceutical; Surfacewater; Wastewater; Hospital effluent

Abstract

V originále

The results of an inter-laboratory comparison exercise to determine cytostatic anticancer drug residues in surface water, hospital wastewater and wastewater treatment plant effluent are reported. To obtain a critical number of participants, an invitation was sent out to potential laboratories identified to have the necessary knowledge and instrumentation. Nine laboratories worldwide confirmed their participation in the exercise. The compounds selected included cyclophosphamide, ifosfamide, 5-fluorouracil, gemcitabine, etoposide, methotrexate and cisplatinum. Samples of spiked waste (hospital and wastewater treatment plant effluent) and surface water, and additional non-spiked hospital wastewater, were prepared by the organising laboratory (JoA3/4ef Stefan Institute) and sent out to each participant partner for analysis. All analytical methods included solid phase extraction (SPE) and the use of surrogate/internal standards for quantification. Chemical analysis was performed using either liquid or gas chromatography mass (MS) or tandem mass (MS/MS) spectrometry. Cisplatinum was determined using inductively coupled plasma mass spectrometry (ICP-MS). A required minimum contribution of five laboratories meant that only cyclophosphamide, ifosfamide, methotrexate and etoposide could be included in the statistical evaluation. z-score and Q test revealed 3 and 4 outliers using classical and robust approach, respectively. The smallest absolute differences between the spiked values and the measured values were observed in the surface water matrix. The highest within-laboratory repeatability was observed for methotrexate in all three matrices (CV a parts per thousand currency signaEuro parts per thousand 12 %). Overall, inter-laboratory reproducibility was poor for all compounds and matrices (CV 27-143 %) with the only exception being methotrexate measured in the spiked hospital wastewater (CV = 8 %). Random and total errors were identified by means of Youden plots.

Links

603437, interní kód MU

Name: SOLUTIONS - Solutions for present and future emerging pollutants in land and water resources management (Acronym: SOLUTIONS)

Investor: European Union, Cooperation

Citovat

HEATH, Ester, Marjeta CESEN, Noelia NEGREIRA, Miren Lopez DE ALDA, Laura FERRANDO-CLIMENT, Lucie BLÁHOVÁ, Tung Viet NGUYEN, Mohamed ADAHCHOUR, Achim RUEBEL, Neville LLEWELLYN, Janez SCANCAR, Srdjan NOVAKOVIC, Vesna MISLEJ, Marjeta STRAZAR, Damia BARCELO and Tina KOSJEK. First inter-laboratory comparison exercise for the determination of anticancer drugs in aqueous samples. Environmental Science and Pollution Research. Landsberg, Germany: Ecomed, 2016, vol. 23, No 15, p. 14692-14704. ISSN 0944-1344. Available from: https://dx.doi.org/10.1007/s11356-015-4982-9.

@article{1372456,
   author = {Heath, Ester and Cesen, Marjeta and Negreira, Noelia and de Alda, Miren Lopez and FerrandoandCliment, Laura and Bláhová, Lucie and Nguyen, Tung Viet and Adahchour, Mohamed and Ruebel, Achim and Llewellyn, Neville and Scancar, Janez and Novakovic, Srdjan and Mislej, Vesna and Strazar, Marjeta and Barcelo, Damia and Kosjek, Tina},
   article_location = {Landsberg, Germany},
   article_number = {15},
   doi = {http://dx.doi.org/10.1007/s11356-015-4982-9},
   keywords = {Inter-laboratory study; Cytostatic; Pharmaceutical; Surfacewater; Wastewater; Hospital effluent},
   language = {eng},
   issn = {0944-1344},
   journal = {Environmental Science and Pollution Research},
   title = {First inter-laboratory comparison exercise for the determination of anticancer drugs in aqueous samples},
   url = {http://link.springer.com/article/10.1007%2Fs11356-015-4982-9},
   volume = {23},
   year = {2016}
}

TY  - JOUR
ID  - 1372456
AU  - Heath, Ester - Cesen, Marjeta - Negreira, Noelia - de Alda, Miren Lopez - Ferrando-Climent, Laura - Bláhová, Lucie - Nguyen, Tung Viet - Adahchour, Mohamed - Ruebel, Achim - Llewellyn, Neville - Scancar, Janez - Novakovic, Srdjan - Mislej, Vesna - Strazar, Marjeta - Barcelo, Damia - Kosjek, Tina
PY  - 2016
TI  - First inter-laboratory comparison exercise for the determination of anticancer drugs in aqueous samples
JF  - Environmental Science and Pollution Research
VL  - 23
IS  - 15
SP  - 14692-14704
EP  - 14692-14704
PB  - Ecomed
SN  - 09441344
KW  - Inter-laboratory study
KW  - Cytostatic
KW  - Pharmaceutical
KW  - Surfacewater
KW  - Wastewater
KW  - Hospital effluent
UR  - http://link.springer.com/article/10.1007%2Fs11356-015-4982-9
L2  - http://link.springer.com/article/10.1007%2Fs11356-015-4982-9
N2  - The results of an inter-laboratory comparison exercise to determine cytostatic anticancer drug residues in surface water, hospital wastewater and wastewater treatment plant effluent are reported. To obtain a critical number of participants, an invitation was sent out to potential laboratories identified to have the necessary knowledge and instrumentation. Nine laboratories worldwide confirmed their participation in the exercise. The compounds selected included cyclophosphamide, ifosfamide, 5-fluorouracil, gemcitabine, etoposide, methotrexate and cisplatinum. Samples of spiked waste (hospital and wastewater treatment plant effluent) and surface water, and additional non-spiked hospital wastewater, were prepared by the organising laboratory (JoA3/4ef Stefan Institute) and sent out to each participant partner for analysis. All analytical methods included solid phase extraction (SPE) and the use of surrogate/internal standards for quantification. Chemical analysis was performed using either liquid or gas chromatography mass (MS) or tandem mass (MS/MS) spectrometry. Cisplatinum was determined using inductively coupled plasma mass spectrometry (ICP-MS). A required minimum contribution of five laboratories meant that only cyclophosphamide, ifosfamide, methotrexate and etoposide could be included in the statistical evaluation. z-score and Q test revealed 3 and 4 outliers using classical and robust approach, respectively. The smallest absolute differences between the spiked values and the measured values were observed in the surface water matrix. The highest within-laboratory repeatability was observed for methotrexate in all three matrices (CV a parts per thousand currency signaEuro parts per thousand 12 %). Overall, inter-laboratory reproducibility was poor for all compounds and matrices (CV 27-143 %) with the only exception being methotrexate measured in the spiked hospital wastewater (CV = 8 %). Random and total errors were identified by means of Youden plots.
ER  -

HEATH, Ester, Marjeta CESEN, Noelia NEGREIRA, Miren Lopez DE ALDA, Laura FERRANDO-CLIMENT, Lucie BLÁHOVÁ, Tung Viet NGUYEN, Mohamed ADAHCHOUR, Achim RUEBEL, Neville LLEWELLYN, Janez SCANCAR, Srdjan NOVAKOVIC, Vesna MISLEJ, Marjeta STRAZAR, Damia BARCELO and Tina KOSJEK. First inter-laboratory comparison exercise for the determination of anticancer drugs in aqueous samples. \textit{Environmental Science and Pollution Research}. Landsberg, Germany: Ecomed, 2016, vol.~23, No~15, p.~14692-14704. ISSN~0944-1344. Available from: https://dx.doi.org/10.1007/s11356-015-4982-9.

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