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@article{1372466, author = {Babica, Pavel and Čtveráčková, Lucie and Lenčešová, Zuzana and Trosko, James E. and Upham, Brad L.}, article_location = {ABINGDON}, article_number = {5}, doi = {http://dx.doi.org/10.1080/01635581.2016.1180409}, keywords = {CELL-CELL COMMUNICATION; CANCER CHEMOPREVENTION; STEM-CELLS; GREEN TEA; H2O2-INDUCED INHIBITION; CHEMICAL CARCINOGENESIS; DOWN-REGULATION; CHEMOTHERAPY; PREVENTION; QUERCETIN}, language = {eng}, issn = {0163-5581}, journal = {Nutrition and cancer : an international journal}, title = {Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants}, url = {http://www.tandfonline.com/doi/abs/10.1080/01635581.2016.1180409?journalCode=hnuc20}, volume = {68}, year = {2016} }
TY - JOUR ID - 1372466 AU - Babica, Pavel - Čtveráčková, Lucie - Lenčešová, Zuzana - Trosko, James E. - Upham, Brad L. PY - 2016 TI - Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants JF - Nutrition and cancer : an international journal VL - 68 IS - 5 SP - 827-837 EP - 827-837 PB - ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD SN - 01635581 KW - CELL-CELL COMMUNICATION KW - CANCER CHEMOPREVENTION KW - STEM-CELLS KW - GREEN TEA KW - H2O2-INDUCED INHIBITION KW - CHEMICAL CARCINOGENESIS KW - DOWN-REGULATION KW - CHEMOTHERAPY KW - PREVENTION KW - QUERCETIN UR - http://www.tandfonline.com/doi/abs/10.1080/01635581.2016.1180409?journalCode=hnuc20 L2 - http://www.tandfonline.com/doi/abs/10.1080/01635581.2016.1180409?journalCode=hnuc20 N2 - Altered gap junctional intercellular communication (GJIC) has been associated with chemical carcinogenesis, where both chemical tumor promoters and chemopreventive agents (CPAs) are known to conversely modulate GJIC. The aim of this study was to investigate whether attenuation of chemically inhibited GJIC represents a common outcome induced by different CPAs, which could be effectively evaluated using in vitro methods. Rat liver epithelial cells WB-F344 were pretreated with a CPA for either 30min or 24h, and then exposed to GJIC-inhibiting concentration of a selected tumor promoter or environmental toxicant [12-O-tetradecanoylphorbol-13-acetate (TPA), lindane, fluoranthene, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT), perfluorooctanoic acid (PFOA), or pentachlorophenol]. Out of nine CPAs tested, quercetin and silibinin elicited the most pronounced effects, preventing the dysregulation of GJIC by all the GJIC inhibitors, but DDT. Metformin and curcumin attenuated the effects of three GJIC inhibitors, whereas the other CPAs prevented the effects of two (diallyl sulfide, emodin) or one (indole-3-carbinol, thymoquinone) GJIC inhibitor. Significant attenuation of chemically induced inhibition of GJIC was observed in 27 (50%) out of 54 possible combinations of nine CPAs and six GJIC inhibitors. Our data demonstrate that in vitro evaluation of GJIC can be used as an effective screening tool for identification of chemicals with potential chemopreventive activity. ER -
BABICA, Pavel, Lucie ČTVERÁČKOVÁ, Zuzana LENČEŠOVÁ, James E. TROSKO and Brad L. UPHAM. Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants. \textit{Nutrition and cancer : an international journal}. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR \&{}amp; FRANCIS LTD, 2016, vol.~68, No~5, p.~827-837. ISSN~0163-5581. Available from: https://dx.doi.org/10.1080/01635581.2016.1180409.
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