Detailed Information on Publication Record
2016
A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination
JUSKO, Todd A., Anneclaire J. DE ROOS, Sue Y. LEE, Kelly THEVENET-MORRISON, Stephen M. SCHWARTZ et. al.Basic information
Original name
A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination
Authors
JUSKO, Todd A. (840 United States of America), Anneclaire J. DE ROOS (840 United States of America), Sue Y. LEE (840 United States of America), Kelly THEVENET-MORRISON (840 United States of America), Stephen M. SCHWARTZ (840 United States of America), Marc-Andre VERNER (124 Canada), Lubica MURÍNOVÁ PÁLKOVIČOVÁ (703 Slovakia), Beata DROBNÁ (703 Slovakia), Anton KOČAN (703 Slovakia, guarantor, belonging to the institution), Anna FABIŠIKOVÁ (703 Slovakia), Kamil ČONKA (703 Slovakia), Tomáš TRNOVEC (703 Slovakia), Irva HERTZ-PICCIOTTO (840 United States of America) and B. Paige LAWRENCE (840 United States of America)
Edition
Environmental health perspectives, USA, US Dept Health Human Sciences, 2016, 0091-6765
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30304 Public and environmental health
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 9.776
RIV identification code
RIV/00216224:14310/16:00093529
Organization unit
Faculty of Science
UT WoS
000377081300025
Keywords in English
POLYCHLORINATED-BIPHENYLS; PERINATAL EXPOSURE; ORGANOCHLORINE PESTICIDES; PCB CONCENTRATIONS; CALMETTE-GUERIN; BCG VACCINATION; IMMUNE-SYSTEM; MISSING LINK; GOAT KIDS; CHILDREN
Tags
International impact, Reviewed
Změněno: 3/3/2017 07:50, Mgr. Michaela Hylsová, Ph.D.
Abstract
V originále
BACKGROUND: Reasons for the highly variable and often poor protection conferred by the Mycobacterium bovis bacille Calmette-Guerin (BCG) vaccine are multifaceted and poorly understood. OBJECTIVES: We aimed to determine whether early-life exposure to PCBs (polychlorinated biphenyls) and DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene] reduces 6-month infant BCG vaccine response. METHODS: Data came from families participating in a prospective birth cohort in eastern Slovakia. At birth, maternal and cord blood were collected for chemical analyses, and infants were immunized with BCG. Blood was collected from infants for chemical analyses and to determine 6-month BCG-specific immunoglobulin (Ig) G and IgA levels. Multivariable linear regression models were fit to examine chemical-BCG associations among approximately 500 mother-infant pairs, with adjustment for confounders. RESULTS: The median 6-month infant concentration of the prevalent congener PCB-153 was 113 ng/g lipid [interquartile range (IQR): 37-248], and 388 ng/g lipid (IQR: 115-847) for DDE. Higher 6-month infant concentrations of PCB-153 and DDE were strongly associated with lower 6-month BCG-specific antibody levels. For instance, BCG-specific IgG levels were 37% lower for infants with PCB-153 concentrations at the 75th percentile compared to the 25th percentile (95% CI: -42, -32; p < 0.001). Results were similar in magnitude and precision for DDE. There was also evidence of PCB-DDE additivity, where exposure to both compounds reduced anti-BCG levels more than exposure to either compound alone. CONCLUSIONS: The associations observed in this study indicate that environmental exposures may be overlooked contributors to poorer responses to BCG vaccine. The overall association between these exposures and tuberculosis incidence is unknown.