J 2017

Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry

GRAEFF, Luisa Durán, Danila SEIDEL, Maria J. G. T. VEHRESCHILD, Axel HAMPRECHT, Anupma KINDO et. al.

Basic information

Original name

Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry

Authors

GRAEFF, Luisa Durán (276 Germany), Danila SEIDEL (276 Germany), Maria J. G. T. VEHRESCHILD (276 Germany), Axel HAMPRECHT (276 Germany), Anupma KINDO (356 India), Zdeněk RÁČIL (203 Czech Republic, guarantor, belonging to the institution), Judit DEMETER (348 Hungary), Sybren De HOOG (528 Netherlands), Ute AURBACH (276 Germany), Maren ZIEGLER (276 Germany), Hilmar WISPLINGHOFF (276 Germany) and Oliver A. CORNELY (276 Germany)

Edition

Mycoses, Hoboken, Wiley-Blackwell, 2017, 0933-7407

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30216 Dermatology and venereal diseases

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.793

RIV identification code

RIV/00216224:14110/17:00096159

Organization unit

Faculty of Medicine

UT WoS

000395433700009

Keywords in English

Geotrichum; invasive fungal diseases; Saprochaete

Tags

Tags

International impact, Reviewed
Změněno: 15/3/2018 16:33, Soňa Böhmová

Abstract

V originále

Saprochaete and Geotrichum spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients and scarce evidence is available for treatment decisions. Among 505 cases of rare IFD from the FungiScope™ registry, we identified 23 cases of invasive infections caused by these fungi reported from 10 countries over a 12-year period. All cases were adults and previous chemotherapy with associated neutropenia was the most common co-morbidity. Fungaemia was confirmed in 14 (61%) cases and deep organ involvement included lungs, liver, spleen, central nervous system and kidneys. Fungi were S. capitata (n=14), S. clavata (n=5), G. candidum (n=2) and Geotrichum spp. (n=2). Susceptibility was tested in 16 (70%) isolates. All S. capitata and S. clavata isolates with the exception of one S. capitata (MIC 4 mg/L) isolate had MICs>32 mg/L for caspofungin. For micafungin and anidulafungin, MICs varied between 0.25 and >32 mg/L. One case was diagnosed postmortem, 22 patients received targeted treatment, with voriconazole as the most frequent first line drug. Overall mortality was 65% (n=15). Initial echinocandin treatment was associated with worse outcome at day 30 when compared to treatment with other antifungals (amphotericin B ± flucytosine, voriconazole, fluconazole and itraconazole) (P=.036). Echinocandins are not an option for these infections.