| POPPOVÁ, Lucie, Pavlína JANOVSKÁ, Karla PLEVOVÁ, Lenka RADOVÁ, Hana PLEŠINGEROVÁ, Marek BORSKÝ, Jana KOTAŠKOVÁ, Barbara KANTOROVÁ, Michaela HLOŽKOVÁ, Jana FIGULOVÁ, Yvona BRYCHTOVÁ, Michaela MÁCHALOVÁ, Milan URÍK, Michael DOUBEK, Alois KOZUBÍK, Šárka POSPÍŠILOVÁ, Šárka PAVLOVÁ and Vítězslav BRYJA. Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV. British journal of haematology. Wiley-Blackwell, 2016, vol. 175, No 5, p. 851-859. ISSN 0007-1048. Available from: https://dx.doi.org/10.1111/bjh.14312. |
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@article{1372867,
author = {Poppová, Lucie and Janovská, Pavlína and Plevová, Karla and Radová, Lenka and Plešingerová, Hana and Borský, Marek and Kotašková, Jana and Kantorová, Barbara and Hložková, Michaela and Figulová, Jana and Brychtová, Yvona and Máchalová, Michaela and Urík, Milan and Doubek, Michael and Kozubík, Alois and Pospíšilová, Šárka and Pavlová, Šárka and Bryja, Vítězslav},
article_number = {5},
doi = {http://dx.doi.org/10.1111/bjh.14312},
keywords = {WNT3; chronic lymphocytic leukaemia; Wnt/beta-catenin pathway; prognostic marker},
language = {eng},
issn = {0007-1048},
journal = {British journal of haematology},
title = {Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV},
volume = {175},
year = {2016}
}
TY - JOUR
ID - 1372867
AU - Poppová, Lucie - Janovská, Pavlína - Plevová, Karla - Radová, Lenka - Plešingerová, Hana - Borský, Marek - Kotašková, Jana - Kantorová, Barbara - Hložková, Michaela - Figulová, Jana - Brychtová, Yvona - Máchalová, Michaela - Urík, Milan - Doubek, Michael - Kozubík, Alois - Pospíšilová, Šárka - Pavlová, Šárka - Bryja, Vítězslav
PY - 2016
TI - Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV
JF - British journal of haematology
VL - 175
IS - 5
SP - 851-859
EP - 851-859
PB - Wiley-Blackwell
SN - 00071048
KW - WNT3
KW - chronic lymphocytic leukaemia
KW - Wnt/beta-catenin pathway
KW - prognostic marker
N2 - The canonical Wnt pathway, dependent on -catenin-controlled transcription, is the most explored Wnt pathway, known to drive the malignant transformation of multiple cell types. Several reports have suggested that this pathway also participates in chronic lymphocytic leukaemia (CLL) pathogenesis. To get a better insight into the role of the Wnt/-catenin pathway in CLL we analysed in detail the expression of the most overexpressed Wnt ligand, encoded by the WNT3 gene, in a well-defined cohort of 137 CLL patients. Our analysis demonstrated that (i) untreated patients with more aggressive disease (with a notable exception of patients with 11q deletion) express less WNT3, (ii) WNT3 declines with disease progression in a significant proportion of patients and (iii) low WNT3 was identified as a strong independent marker indicating shorter treatment-free survival in CLL patients with IGHV mutation. Interestingly, CLL-related lymphoid cell lines, but not stromal cells, failed to respond to the ligand-induced activation of the Wnt/-catenin pathway. This opens the possibility that CLL cells use Wnt-3 to communicate with the cells in the microenvironment. We thus propose that the Wnt/-catenin pathway plays a more complex role in CLL pathogenesis than previously anticipated.
ER -
POPPOVÁ, Lucie, Pavlína JANOVSKÁ, Karla PLEVOVÁ, Lenka RADOVÁ, Hana PLEŠINGEROVÁ, Marek BORSKÝ, Jana KOTAŠKOVÁ, Barbara KANTOROVÁ, Michaela HLOŽKOVÁ, Jana FIGULOVÁ, Yvona BRYCHTOVÁ, Michaela MÁCHALOVÁ, Milan URÍK, Michael DOUBEK, Alois KOZUBÍK, Šárka POSPÍŠILOVÁ, Šárka PAVLOVÁ and Vítězslav BRYJA. Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV. \textit{British journal of haematology}. Wiley-Blackwell, 2016, vol.~175, No~5, p.~851-859. ISSN~0007-1048. Available from: https://dx.doi.org/10.1111/bjh.14312.
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