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@article{1373093,
author = {Hart, Radek and Safi, Adel Mohammad Mahmoud and Jajtner, Pavel and Puskeiler, Miloš and Hartová, Petra and Komzák, Martin},
article_location = {Philadelphia},
article_number = {1},
doi = {http://dx.doi.org/10.1097/BCO.0000000000000457},
keywords = {cartilage; HA; knee; PRP; second look arthroscopy},
language = {eng},
issn = {1940-7041},
journal = {Current Orthopaedic Practice},
title = {Tibiofemoral chondromalacia treated with platelet-rich plasma and hyaluronic acid},
url = {http://dx.doi.org/10.1097/BCO.0000000000000457},
volume = {28},
year = {2017}
}
TY - JOUR
ID - 1373093
AU - Hart, Radek - Safi, Adel Mohammad Mahmoud - Jajtner, Pavel - Puskeiler, Miloš - Hartová, Petra - Komzák, Martin
PY - 2017
TI - Tibiofemoral chondromalacia treated with platelet-rich plasma and hyaluronic acid
JF - Current Orthopaedic Practice
VL - 28
IS - 1
SP - 58-65
EP - 58-65
PB - Lippincott Williams and Wilkins
SN - 19407041
KW - cartilage
KW - HA
KW - knee
KW - PRP
KW - second look arthroscopy
UR - http://dx.doi.org/10.1097/BCO.0000000000000457
L2 - http://dx.doi.org/10.1097/BCO.0000000000000457
N2 - Background: The objective of the present study was to determine if platelet rich plasma (PRP) can increase tibiofemoral cartilage regeneration and improve knee function. Methods: Fourty consecutive and strictly selected patients affected by grade II or III chondromalacia underwent 1 yr of treatment (nine injections) with autologous PRP in a liquid form with 2.0 to 2.5-fold platelet concentration (20 cases) or with hyaluronic acid (HA) (20 patients). Outcome measures included the Lysholm, Tegner, International Knee Documentation Committee (IKDC), Western Ontario and McMaster (WOMAC) Osteoarthritis Index, and Short Form (SF)-36 scores. MRI arthroscopic and histologic assessment were used to evaluate cartilage thickness and degree of degeneration before and after treatment (1 yr after the primary arthroscopy). Results: The study demonstrated significant improvement in Lysholm, Tegner, IKDC, WOMAC, and SF-36 scores in both groups. Cartilage assessment revealed no significant macroscopic or microscopic structural regeneration as well as no cartilage height increase in either group. Higher content of chondrocytes and proteoglycans in cartilage was proven in both groups after treatment without a statistically significant difference between the groups. There were no adverse events observed. Conclusions: PRP and HA significantly reduced pain and improved quality of life in patients with a low degree of cartilage degeneration. MRI and arthroscopic assessment did not confirm any significant cartilage structural improvement. The content of chondrocytes and proteoglycans in cartilage was higher in the PRP group than in the HA group after the treatment but did not reach statistical significance.
ER -
HART, Radek, Adel Mohammad Mahmoud SAFI, Pavel JAJTNER, Miloš PUSKEILER, Petra HARTOVÁ a Martin KOMZÁK. Tibiofemoral chondromalacia treated with platelet-rich plasma and hyaluronic acid. \textit{Current Orthopaedic Practice}. Philadelphia: Lippincott Williams and Wilkins, 2017, roč.~28, č.~1, s.~58-65. ISSN~1940-7041. Dostupné z: https://dx.doi.org/10.1097/BCO.0000000000000457.
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