HART, Radek, Adel Mohammad Mahmoud SAFI, Pavel JAJTNER, Miloš PUSKEILER, Petra HARTOVÁ and Martin KOMZÁK. Tibiofemoral chondromalacia treated with platelet-rich plasma and hyaluronic acid. Current Orthopaedic Practice. Philadelphia: Lippincott Williams and Wilkins, 2017, vol. 28, No 1, p. 58-65. ISSN 1940-7041. Available from: https://dx.doi.org/10.1097/BCO.0000000000000457.
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Basic information
Original name Tibiofemoral chondromalacia treated with platelet-rich plasma and hyaluronic acid
Authors HART, Radek, Adel Mohammad Mahmoud SAFI, Pavel JAJTNER, Miloš PUSKEILER, Petra HARTOVÁ and Martin KOMZÁK.
Edition Current Orthopaedic Practice, Philadelphia, Lippincott Williams and Wilkins, 2017, 1940-7041.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30211 Orthopaedics
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1097/BCO.0000000000000457
UT WoS 000399086100012
Keywords in English cartilage; HA; knee; PRP; second look arthroscopy
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 17/5/2018 15:51.
Abstract
Background: The objective of the present study was to determine if platelet rich plasma (PRP) can increase tibiofemoral cartilage regeneration and improve knee function. Methods: Fourty consecutive and strictly selected patients affected by grade II or III chondromalacia underwent 1 yr of treatment (nine injections) with autologous PRP in a liquid form with 2.0 to 2.5-fold platelet concentration (20 cases) or with hyaluronic acid (HA) (20 patients). Outcome measures included the Lysholm, Tegner, International Knee Documentation Committee (IKDC), Western Ontario and McMaster (WOMAC) Osteoarthritis Index, and Short Form (SF)-36 scores. MRI arthroscopic and histologic assessment were used to evaluate cartilage thickness and degree of degeneration before and after treatment (1 yr after the primary arthroscopy). Results: The study demonstrated significant improvement in Lysholm, Tegner, IKDC, WOMAC, and SF-36 scores in both groups. Cartilage assessment revealed no significant macroscopic or microscopic structural regeneration as well as no cartilage height increase in either group. Higher content of chondrocytes and proteoglycans in cartilage was proven in both groups after treatment without a statistically significant difference between the groups. There were no adverse events observed. Conclusions: PRP and HA significantly reduced pain and improved quality of life in patients with a low degree of cartilage degeneration. MRI and arthroscopic assessment did not confirm any significant cartilage structural improvement. The content of chondrocytes and proteoglycans in cartilage was higher in the PRP group than in the HA group after the treatment but did not reach statistical significance.
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