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@article{1373188, author = {Horská, Kateřina and Rudá, Jana and Karpisek, Michal and Opatřilová, Radka and Suchý, Pavel and Kotolová, Hana}, article_location = {London}, article_number = {4}, doi = {http://dx.doi.org/10.1177/0269881117691466}, keywords = {Adipokine; depot risperidone; leptin; lipid profile; Sprague-Dawley rats}, language = {eng}, issn = {0269-8811}, journal = {Journal of Psychopharmacology}, title = {Depot risperidone-induced adverse metabolic alterations in female rats}, url = {http://journals.sagepub.com/doi/10.1177/0269881117691466}, volume = {31}, year = {2017} }
TY - JOUR ID - 1373188 AU - Horská, Kateřina - Rudá, Jana - Karpisek, Michal - Opatřilová, Radka - Suchý, Pavel - Kotolová, Hana PY - 2017 TI - Depot risperidone-induced adverse metabolic alterations in female rats JF - Journal of Psychopharmacology VL - 31 IS - 4 SP - 487-499 EP - 487-499 PB - SAGE Publications Ltd. SN - 02698811 KW - Adipokine KW - depot risperidone KW - leptin KW - lipid profile KW - Sprague-Dawley rats UR - http://journals.sagepub.com/doi/10.1177/0269881117691466 L2 - http://journals.sagepub.com/doi/10.1177/0269881117691466 N2 - Atypical antipsychotics are associated with adverse metabolic effects including weight gain, increased adiposity, dyslipidaemia, alterations in glucose metabolism and insulin resistance. Increasing evidence suggests that metabolic dysregulation precedes weight gain development. The aim of this study was to evaluate alterations in adipokines, hormones and basic serum biochemical parameters induced by chronic treatment with depot risperidone at two doses (20 and 40 mg/kg) in female Sprague–Dawley rats. Dose-dependent metabolic alterations induced by risperidone after 6 weeks of treatment were revealed. Concomitant to weight gain and increased liver weight, an adverse lipid profile with an elevated triglyceride level was observed in the high exposure group, administered a 40 mg/kg dose repeatedly, while the low dose exposure group, administered a 20 mg/kg dose, developed weight gain without alterations in the lipid profile and adipokine levels. An initial peak in leptin serum level after the higher dose was observed in the absence of weight gain. This finding may indicate that the metabolic alterations observed in this study are not consequent to body weight gain. Taken together, these data may support the primary effects of atypical antipsychotics on peripheral tissues. ER -
HORSKÁ, Kateřina, Jana RUDÁ, Michal KARPISEK, Radka OPATŘILOVÁ, Pavel SUCHÝ and Hana KOTOLOVÁ. Depot risperidone-induced adverse metabolic alterations in female rats. \textit{Journal of Psychopharmacology}. London: SAGE Publications Ltd., 2017, vol.~31, No~4, p.~487-499. ISSN~0269-8811. Available from: https://dx.doi.org/10.1177/0269881117691466.
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