Redox Processes of Guanine Moieties in DNA Heptamers Related to
Hydrogen Evolution

J 2016

Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution

TŘÍSKOVÁ, Iveta, Radovan FIALA and Libuše TRNKOVÁ

Basic information

Original name

Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution

Authors

TŘÍSKOVÁ, Iveta (203 Czech Republic, belonging to the institution), Radovan FIALA (203 Czech Republic, belonging to the institution) and Libuše TRNKOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Electroanalysis, 2016, 1040-0397

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10403 Physical chemistry

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.851

RIV identification code

RIV/00216224:14310/16:00093647

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1002/elan.201600321

UT WoS

000387891400028

Keywords (in Czech)

vlásenky; NMR DNA heptamerů; cyklická voltametrie; vylučování vodíku; potenciál bodu obratu; neurodegenerativní onemocnění

Keywords in English

Hairpins; NMR of DNA heptamers; cyclic voltammetry; hydrogen evolution reaction; vertex potential; neurodegenerative diseases

Abstract

V originále

The paper is focused on the electrochemical investigation of DNA heptamers d(GCXXXGC) with different central triplets of nucleotides (XXX=GAA, AAA, CCC, GGG). On a hanging mercury electrode (HMDE), the reduction peaks of adenine (A) and cytosine (C) moieties are detectable, but those of guanine (G) moieties are covered by an intensive current of hydrogen evolution. Because cyclic voltammetry allows us to monitor only the oxidation processes of the G reduced species, the effect of hydrogen evolution reaction (HER) was studied by means of these anodic signals. For different vertex potentials (from -1.60V to -1.85V) and a different number of cycles (1-5), all heptamers in buffered solutions (pH5.8) were tested and double-peak G oxidation signals (GI and GII) evaluated. The different structures of the heptamers in solutions are confirmed by NMR spectra. Both the impact of hydrogen evolution into the production of 7,8-dihydroguanine moieties forming together with hydrogen in negative potentials and the catalytic effect of heptamers on hydrogen evolution are discussed.

Citovat

TŘÍSKOVÁ, Iveta, Radovan FIALA and Libuše TRNKOVÁ. Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution. Electroanalysis. 2016, vol. 28, No 11, p. 2841-2848. ISSN 1040-0397. Available from: https://dx.doi.org/10.1002/elan.201600321.

@article{1373345,
   author = {Třísková, Iveta and Fiala, Radovan and Trnková, Libuše},
   article_number = {11},
   doi = {http://dx.doi.org/10.1002/elan.201600321},
   keywords = {Hairpins; NMR of DNA heptamers; cyclic voltammetry; hydrogen evolution reaction; vertex potential; neurodegenerative diseases},
   language = {eng},
   issn = {1040-0397},
   journal = {Electroanalysis},
   title = {Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution},
   url = {http://onlinelibrary.wiley.com/doi/10.1002/elan.201600321/full},
   volume = {28},
   year = {2016}
}

TY  - JOUR
ID  - 1373345
AU  - Třísková, Iveta - Fiala, Radovan - Trnková, Libuše
PY  - 2016
TI  - Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution
JF  - Electroanalysis
VL  - 28
IS  - 11
SP  - 2841-2848
EP  - 2841-2848
SN  - 10400397
KW  - Hairpins
KW  - NMR of DNA heptamers
KW  - cyclic voltammetry
KW  - hydrogen evolution reaction
KW  - vertex potential
KW  - neurodegenerative diseases
UR  - http://onlinelibrary.wiley.com/doi/10.1002/elan.201600321/full
L2  - http://onlinelibrary.wiley.com/doi/10.1002/elan.201600321/full
N2  - The paper is focused on the electrochemical investigation of DNA heptamers d(GCXXXGC) with different central triplets of nucleotides (XXX=GAA, AAA, CCC, GGG). On a hanging mercury electrode (HMDE), the reduction peaks of adenine (A) and cytosine (C) moieties are detectable, but those of guanine (G) moieties are covered by an intensive current of hydrogen evolution. Because cyclic voltammetry allows us to monitor only the oxidation processes of the G reduced species, the effect of hydrogen evolution reaction (HER) was studied by means of these anodic signals. For different vertex potentials (from -1.60V to -1.85V) and a different number of cycles (1-5), all heptamers in buffered solutions (pH5.8) were tested and double-peak G oxidation signals (GI and GII) evaluated. The different structures of the heptamers in solutions are confirmed by NMR spectra. Both the impact of hydrogen evolution into the production of 7,8-dihydroguanine moieties forming together with hydrogen in negative potentials and the catalytic effect of heptamers on hydrogen evolution are discussed.
ER  -

TŘÍSKOVÁ, Iveta, Radovan FIALA and Libuše TRNKOVÁ. Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution. \textit{Electroanalysis}. 2016, vol.~28, No~11, p.~2841-2848. ISSN~1040-0397. Available from: https://dx.doi.org/10.1002/elan.201600321.

Detailed Information on Publication Record