The pilot study deals with optimization of prescription of PA in breast cancer survivors. It includes type of exercise, duration of session, intensity and frequency and its impact on chosen physiological parameters. 15 breast cancer survivors was enrolled to 6 months intensive PA program leaded by staff of Faculty of Sports Studies. Frequency of sessions was 3 x weeks, the duration of each session was 60 minutes. The type of PA was 1x harmonization exercises and 2x aerobic activities. The intensity of PA in aerobic sessions was assessed according to spiroergometry load test of each individual. For evaluation of positive impact of physical activity on physiological parameters following tests were made: Spiroergometry load test, body composition by bioimpedance measurement, test of activity of autonomous nerve system, isokinetic dynamometry. All the tests were made in the beginning, after 3 months and in the end of intervention.