HRUŠKA, Pavel, Filip ZLÁMAL, Vladimír VAŠKŮ a Julie BIENERTOVÁ VAŠKŮ. No association of the SNP rs1048261 within 3´UTR of HSPB7 with cardiovascular morbidity in patients with psoriasis; a possible effect on miRNA-mediated translational regulation. Global Dermatology, Rome: University of Rome, 2016, roč. 3, č. 2, s. 281-285. ISSN 2056-7863. doi:10.15761/GOD.1000175.
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Základní údaje
Originální název No association of the SNP rs1048261 within 3´UTR of HSPB7 with cardiovascular morbidity in patients with psoriasis; a possible effect on miRNA-mediated translational regulation
Autoři HRUŠKA, Pavel (203 Česká republika, domácí), Filip ZLÁMAL (203 Česká republika, domácí), Vladimír VAŠKŮ (203 Česká republika, domácí) a Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, garant, domácí).
Vydání Global Dermatology, Rome, University of Rome, 2016, 2056-7863.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30216 Dermatology and venereal diseases
Stát vydavatele Itálie
Utajení není předmětem státního či obchodního tajemství
WWW URL
Kód RIV RIV/00216224:14110/16:00093761
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.15761/GOD.1000175
Klíčová slova anglicky HSPB7; SNP; rs1048261; miRNA; microRNA; psoriasis; cardiovascular disease; comorbidity
Štítky EL OK, podil
Změnil Změnila: Soňa Böhmová, učo 232884. Změněno: 17. 3. 2017 11:04.
Anotace
Previous studies have shown an increased risk of cardiovascular diseases in patients with psoriasis. It has also been known that abnormal levels of microRNA (miRNA) contribute to the pathogenesis of psoriasis and its comorbidities. Moreover, single nucleotide polymorphisms(SNPs) within miRNA genes or 3’UTR of the miRNA target genes can alter gene expression and thus contribute to the pathogenesis of the disease. Assess SNP rs1048261 within the 3’UTR of HSPB7 in a large cohort (n=558) of psoriatic patients of Central European Caucasian origin and evaluate its possible role in the increased risk of cardiovascular disease (CVD) in psoriasis patients. This study included 558 patients diagnosed with psoriasis; 30% of the patients had a personal history of CVD. In silico analysis was used to determine a candidate SNP which is associated with a potential impairment of miRNA-mediated translational regulation. The chosen SNP rs1048261 was genotyped using PCR-RFLP and all statistical analyses were performed using statistical software R. Possible interactions of the genotype and personal history of CVD were tested, but no significant association was found. Subsequently, the linical subtypes of psoriasis (plaque psoriasis, pustular psoriasis and guttate psoriasis) as well as age at psoriasis onset were analyzed to associate the genotype with CVD, but neither association was found to be statistically significant. Finally, the logistic regression model was created to test any possible associations with the personal history of CVD, but all results were inconclusive. Although our study did not provide any significant association of the SNP rs1048261 with cardiovascular morbidity, we suggest investigating this polymorphism in a cohort of patients with properly diagnosed cardiovascular diseases independently of psoriasis. Also, the validation of miRNA-mRNA interaction and SNP rs1048261 involvement needs to be studied.
Návaznosti
EF15_003/0000469, projekt VaVNázev: Cetocoen Plus
LM2011028, projekt VaVNázev: RECETOX ? Národní infrastruktura pro výzkum toxických látek v prostředí
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Velké infrastruktury pro výzkum, vývoj a inovace
Typ Název Vložil/a Vloženo Práva
No_association.pdf  Böhmová, S. 17. 3. 2017

Práva

Právo číst
  • osoba Mgr. Michaela Hylsová, Ph.D., učo 211937
  • osoba Ing. Mgr. Věra Pospíšilíková, učo 9005
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Právo spravovat
  • osoba Soňa Böhmová, učo 232884
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Požádat autora o autorský výtisk Zobrazeno: 24. 9. 2020 04:28