| KOVÁŘ, David, Aneta MALÁ, Jitka VAŇÁČKOVÁ, Michal KALINA, Zdenka FOHLEROVÁ, Antonín HLAVÁČEK, Zdeněk FARKA, Petr SKLÁDAL, Zenon STARČUK, Radovan JIŘÍK, Ondřej SLABÝ and Jaromír HUBÁLEK. Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging. Journal of Nanomaterials. London: Hindawi Publishing Corporation, 2017, vol. 2017, neuvedeno, p. nestránkováno, 8 pp. ISSN 1687-4110. Available from: https://dx.doi.org/10.1155/2017/7859289. |
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@article{1374448,
author = {Kovář, David and Malá, Aneta and Vaňáčková, Jitka and Kalina, Michal and Fohlerová, Zdenka and Hlaváček, Antonín and Farka, Zdeněk and Skládal, Petr and Starčuk, Zenon and Jiřík, Radovan and Slabý, Ondřej and Hubálek, Jaromír},
article_location = {London},
article_number = {neuvedeno},
doi = {http://dx.doi.org/10.1155/2017/7859289},
keywords = {ATOMIC-FORCE MICROSCOPY; CONTRAST AGENTS; ONE-STEP; MEDIA; MRI; SEPARATION; PARTICLES; SILICA; PROBES; CHARGE},
language = {eng},
issn = {1687-4110},
journal = {Journal of Nanomaterials},
title = {Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging},
url = {https://www.hindawi.com/journals/jnm/2017/7859289/},
volume = {2017},
year = {2017}
}
TY - JOUR
ID - 1374448
AU - Kovář, David - Malá, Aneta - Vaňáčková, Jitka - Kalina, Michal - Fohlerová, Zdenka - Hlaváček, Antonín - Farka, Zdeněk - Skládal, Petr - Starčuk, Zenon - Jiřík, Radovan - Slabý, Ondřej - Hubálek, Jaromír
PY - 2017
TI - Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
JF - Journal of Nanomaterials
VL - 2017
IS - neuvedeno
SP - nestránkováno
EP - nestránkováno
PB - Hindawi Publishing Corporation
SN - 16874110
KW - ATOMIC-FORCE MICROSCOPY
KW - CONTRAST AGENTS
KW - ONE-STEP
KW - MEDIA
KW - MRI
KW - SEPARATION
KW - PARTICLES
KW - SILICA
KW - PROBES
KW - CHARGE
UR - https://www.hindawi.com/journals/jnm/2017/7859289/
L2 - https://www.hindawi.com/journals/jnm/2017/7859289/
N2 - Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. Thecitrate-stabilised particles were produced with a narrow average size range below 2nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI)was then evaluated. The relaxivities (r(1),r(2)) and r(2)/r(1) ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T-2-contrast probe.
ER -
KOVÁŘ, David, Aneta MALÁ, Jitka VAŇÁČKOVÁ, Michal KALINA, Zdenka FOHLEROVÁ, Antonín HLAVÁČEK, Zdeněk FARKA, Petr SKLÁDAL, Zenon STARČUK, Radovan JIŘÍK, Ondřej SLABÝ and Jaromír HUBÁLEK. Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging. \textit{Journal of Nanomaterials}. London: Hindawi Publishing Corporation, 2017, vol.~2017, neuvedeno, p.~nestránkováno, 8 pp. ISSN~1687-4110. Available from: https://dx.doi.org/10.1155/2017/7859289.
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