Preparation and Characterisation of Highly Stable Iron Oxide
Nanoparticles for Magnetic Resonance Imaging

J 2017

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

KOVÁŘ, David, Aneta MALÁ, Jitka VAŇÁČKOVÁ, Michal KALINA, Zdenka FOHLEROVÁ et. al.

Basic information

Original name

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Authors

KOVÁŘ, David (203 Czech Republic, belonging to the institution), Aneta MALÁ (203 Czech Republic), Jitka VAŇÁČKOVÁ (203 Czech Republic, belonging to the institution), Michal KALINA (203 Czech Republic), Zdenka FOHLEROVÁ (203 Czech Republic), Antonín HLAVÁČEK (203 Czech Republic, belonging to the institution), Zdeněk FARKA (203 Czech Republic, belonging to the institution), Petr SKLÁDAL (203 Czech Republic, belonging to the institution), Zenon STARČUK (203 Czech Republic), Radovan JIŘÍK (203 Czech Republic), Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution) and Jaromír HUBÁLEK (203 Czech Republic)

Edition

Journal of Nanomaterials, London, Hindawi Publishing Corporation, 2017, 1687-4110

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.207

RIV identification code

RIV/00216224:14740/17:00094662

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1155/2017/7859289

UT WoS

000396144500001

Keywords in English

ATOMIC-FORCE MICROSCOPY; CONTRAST AGENTS; ONE-STEP; MEDIA; MRI; SEPARATION; PARTICLES; SILICA; PROBES; CHARGE

Abstract

V originále

Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. Thecitrate-stabilised particles were produced with a narrow average size range below 2nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI)was then evaluated. The relaxivities (r(1),r(2)) and r(2)/r(1) ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T-2-contrast probe.

Links

GA16-18257S, research and development project

Name: Studium mechanizmu spojeného s nádorově supresorovou funkcí miR-215 a substituce této miRNA jako nové lečebné strategie u kolorektálního karcinomu

Investor: Czech Science Foundation

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

KOVÁŘ, David, Aneta MALÁ, Jitka VAŇÁČKOVÁ, Michal KALINA, Zdenka FOHLEROVÁ, Antonín HLAVÁČEK, Zdeněk FARKA, Petr SKLÁDAL, Zenon STARČUK, Radovan JIŘÍK, Ondřej SLABÝ and Jaromír HUBÁLEK. Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging. Journal of Nanomaterials. London: Hindawi Publishing Corporation, 2017, vol. 2017, neuvedeno, p. nestránkováno, 8 pp. ISSN 1687-4110. Available from: https://dx.doi.org/10.1155/2017/7859289.

@article{1374448,
   author = {Kovář, David and Malá, Aneta and Vaňáčková, Jitka and Kalina, Michal and Fohlerová, Zdenka and Hlaváček, Antonín and Farka, Zdeněk and Skládal, Petr and Starčuk, Zenon and Jiřík, Radovan and Slabý, Ondřej and Hubálek, Jaromír},
   article_location = {London},
   article_number = {neuvedeno},
   doi = {http://dx.doi.org/10.1155/2017/7859289},
   keywords = {ATOMIC-FORCE MICROSCOPY; CONTRAST AGENTS; ONE-STEP; MEDIA; MRI; SEPARATION; PARTICLES; SILICA; PROBES; CHARGE},
   language = {eng},
   issn = {1687-4110},
   journal = {Journal of Nanomaterials},
   title = {Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging},
   url = {https://www.hindawi.com/journals/jnm/2017/7859289/},
   volume = {2017},
   year = {2017}
}

TY  - JOUR
ID  - 1374448
AU  - Kovář, David - Malá, Aneta - Vaňáčková, Jitka - Kalina, Michal - Fohlerová, Zdenka - Hlaváček, Antonín - Farka, Zdeněk - Skládal, Petr - Starčuk, Zenon - Jiřík, Radovan - Slabý, Ondřej - Hubálek, Jaromír
PY  - 2017
TI  - Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
JF  - Journal of Nanomaterials
VL  - 2017
IS  - neuvedeno
SP  - nestránkováno
EP  - nestránkováno
PB  - Hindawi Publishing Corporation
SN  - 16874110
KW  - ATOMIC-FORCE MICROSCOPY
KW  - CONTRAST AGENTS
KW  - ONE-STEP
KW  - MEDIA
KW  - MRI
KW  - SEPARATION
KW  - PARTICLES
KW  - SILICA
KW  - PROBES
KW  - CHARGE
UR  - https://www.hindawi.com/journals/jnm/2017/7859289/
L2  - https://www.hindawi.com/journals/jnm/2017/7859289/
N2  - Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. Thecitrate-stabilised particles were produced with a narrow average size range below 2nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI)was then evaluated. The relaxivities (r(1),r(2)) and r(2)/r(1) ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T-2-contrast probe.
ER  -

KOVÁŘ, David, Aneta MALÁ, Jitka VAŇÁČKOVÁ, Michal KALINA, Zdenka FOHLEROVÁ, Antonín HLAVÁČEK, Zdeněk FARKA, Petr SKLÁDAL, Zenon STARČUK, Radovan JIŘÍK, Ondřej SLABÝ and Jaromír HUBÁLEK. Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging. \textit{Journal of Nanomaterials}. London: Hindawi Publishing Corporation, 2017, vol.~2017, neuvedeno, p.~nestránkováno, 8 pp. ISSN~1687-4110. Available from: https://dx.doi.org/10.1155/2017/7859289.

Detailed Information on Publication Record