J 2017

Proliferative kidney disease in rainbow trout (Oncorhynchus mykiss) under intensive breeding conditions: Pathogenesis and haematological and immune parameters

PALÍKOVÁ, Miroslava, Ivana PAPEŽÍKOVÁ, Zdeňka MARKOVÁ, Stanislav NAVRÁTIL, Jan MAREŠ et. al.

Basic information

Original name

Proliferative kidney disease in rainbow trout (Oncorhynchus mykiss) under intensive breeding conditions: Pathogenesis and haematological and immune parameters

Authors

PALÍKOVÁ, Miroslava (203 Czech Republic, guarantor), Ivana PAPEŽÍKOVÁ (203 Czech Republic), Zdeňka MARKOVÁ (203 Czech Republic), Stanislav NAVRÁTIL (203 Czech Republic), Jan MAREŠ (203 Czech Republic), Lukáš MAREŠ (203 Czech Republic), Libor VOJTEK (203 Czech Republic, belonging to the institution), Pavel HYRŠL (203 Czech Republic, belonging to the institution), Eva JELÍNKOVÁ (203 Czech Republic) and Heike SCHMIDT-POSTHAUS (756 Switzerland)

Edition

Veterinary Parasitology, Amsterdam, Elsevier Science, 2017, 0304-4017

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.422

RIV identification code

RIV/00216224:14310/17:00096260

Organization unit

Faculty of Science

DOI

UT WoS

000403117800002

Keywords (in Czech)

Proliferativní onemocnění ledvin; pstruh duhový; oxidační vzplanutí; celkové imunoglobuliny; aktivita komplementu; histologie; imunochemie

Keywords in English

Proliferative kidney disease; Rainbow trout; Oxidative burst; Total immunoglobulins; Complement activity; Histology; Immunohistochemistry

Tags

Tags

International impact, Reviewed
Změněno: 10/4/2018 23:03, Ing. Nicole Zrilić

Abstract

V originále

Proliferative kidney disease (PKD) is an endoparasitic disease of salmonid fish caused by Tetracapsuloides bryosalmonae (Myxozoa: Malacosporea). This study presents a comprehensive view on PKD development in rainbow trout (Oncorhynchus mykiss) reared at an intensive fish breeding facility, with focus on mortality, pathology/histopathology, haematological findings and immune functions. Diseased and reference fish were sampled monthly and time course of natural infection was followed up from the onset of clinical signs (September 2014) to full recovery (January 2015). PKD- associated cumulative mortality was 30% with a peak value in October, while immunohistochemical testing indicated a continuous significant decrease in T. bryosalmonae numbers from September to December; with no parasites detected in January. During peak clinical infection, a significant decrease in red blood cell counts, haematocrit values, haemoglobin concentration, along with a reduction in lymphocytes and a significant phagocyte elevation corresponding with an increase in phagocyte oxidative burst were measured in comparison to control animals. Complement activity and total immunoglobulin plasma concentrations were also elevated, though only during the initial monitoring period (September). Individuals surviving PKD, recovered and were able to fully regenerate both renal structure and haematopoietic parameters to normal levels. Changes in the red blood cell parameters indicate anaemia and a decreased oxygen transportation capacity during the clinical disease phase. Together with an increased oxygen demand at higher temperatures and decreased oxygen solubility this could lead to decompensation and elevated mortality. The stimulation of immune parameters, and especially oxidative phagocytic burst, is likely to have had a strong effect on both, regeneration and elimination of the pathogenic agent.