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@proceedings{1374973,
author = {Vaculovič, Tomáš and Tvrdoňová, Michaela and Masařík, Michal and Polanská, Hana and Svobodová, Markéta and Gumulec, Jaromír and Kanický, Viktor and Čadková, Zuzana and Otruba, Vítězslav and Száková, Jiřina},
booktitle = {European Symposium on Atomic Spectrometry},
keywords = {Trends and new techniques of atomic spectrometry; Atomic absorption; atomic fluorescence; atomic emission methods; X-ray spectrometry; Mass spectrometry;},
language = {eng},
title = {Utilization of LA-ICP-MS for bioimaging},
year = {2016}
}
TY - CONF
ID - 1374973
AU - Vaculovič, Tomáš - Tvrdoňová, Michaela - Masařík, Michal - Polanská, Hana - Svobodová, Markéta - Gumulec, Jaromír - Kanický, Viktor - Čadková, Zuzana - Otruba, Vítězslav - Száková, Jiřina
PY - 2016
TI - Utilization of LA-ICP-MS for bioimaging
KW - Trends and new techniques of atomic spectrometry
KW - Atomic absorption
KW - atomic fluorescence
KW - atomic emission methods
KW - X-ray spectrometry
KW - Mass spectrometry;
N2 - Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) represents one of the most suitable method for study of lateral distribution of specific elements (Cu, Zn, Pb, Pt...) in low concentration levels (tens mg/kg) in various biological tissues. Presented work is focused on study of influence of scan speed and laser spot diameter on lateral resolution, LOD, and time consumption of analysis. The utilization of LA-ICP-MS for bioimaging purpose will be demonstrated on two different types of the matrices. First one is tumour tissue which is treated by various Pt-based cytostatics (carbo-, oxali- and cis-Pt). The second one are cuts of tapeworm treated by various heavy metals.
ER -
VACULOVIČ, Tomáš, Michaela TVRDOŇOVÁ, Michal MASAŘÍK, Hana POLANSKÁ, Markéta SVOBODOVÁ, Jaromír GUMULEC, Viktor KANICKÝ, Zuzana ČADKOVÁ, Vítězslav OTRUBA and Jiřina SZÁKOVÁ. Utilization of LA-ICP-MS for bioimaging. In \textit{European Symposium on Atomic Spectrometry}. 2016.
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