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@proceedings{1374979, author = {Vaculovič, Tomáš and Tvrdoňová, Michaela and Masařík, Michal and Polanská, Hana and Svobodová, Markéta and Kanický, Viktor}, booktitle = {European Workshop on Laser Ablation}, keywords = {laser-matter interaction; particle formation and transport phenomena; mapping strategies; standardization; isotope ratio analysis;}, language = {eng}, title = {LA-ICP-MS as a tool for imaging of tumour tissue}, year = {2016} }
TY - CONF ID - 1374979 AU - Vaculovič, Tomáš - Tvrdoňová, Michaela - Masařík, Michal - Polanská, Hana - Svobodová, Markéta - Kanický, Viktor PY - 2016 TI - LA-ICP-MS as a tool for imaging of tumour tissue KW - laser-matter interaction KW - particle formation and transport phenomena KW - mapping strategies KW - standardization KW - isotope ratio analysis; N2 - Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) allows study of lateral distribution of specific elements (Cu, Zn, Pb, Pt) in very low concentration levels (mg/kg) in tumor tissues. Presented work is focused on study of laser ablation parameters (scan speed and laser spot diameter) on lateral resolution and limit of detection of LA-ICP-MS. The utilization of LA-ICP-MS for bioimaging purpose will be demonstrated on mice tumour tissues analysis which are treated by various Pt-based cytostatics (carbo-, oxali- and cis-Pt). ER -
VACULOVIČ, Tomáš, Michaela TVRDOŇOVÁ, Michal MASAŘÍK, Hana POLANSKÁ, Markéta SVOBODOVÁ and Viktor KANICKÝ. LA-ICP-MS as a tool for imaging of tumour tissue. In \textit{European Workshop on Laser Ablation}. 2016.
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