MACHIELA, Mitchell J., Qing LAN, Susan L. SLAGER, Roel C. H. VERMEULEN, Lauren R. TERAS, Nicola J. CAMP, James R. CERHAN, John J. SPINELLI, Sophia S. WANG, Alexandra NIETERS, Joseph VIJAI, Meredith YEAGER, Zhaoming WANG, Hervé GHESQUIÈRES, James MCKAY, Lucia CONDE, Paul I. W. de BAKKER, David G. COX, Laurie BURDETT, Alain MONNEREAU, Christopher R. FLOWERS, Anneclaire J. De ROOS, Angela R. BROOKS-WILSON, Graham G. GILES, Mads MELBYE, Jian GU, Rebecca D. JACKSON, Eleanor KANE, Mark P. PURDUE, Claire M. VAJDIC, Demetrius ALBANES, Rachel S. KELLY, Mariagrazia ZUCCA, Kimberly A. BERTRAND, Anne ZELENIUCH-JACQUOTTE, Charles LAWRENCE, Amy HUTCHINSON, Degui ZHI, Thomas M. HABERMANN, Brian K. LINK, Anne J. NOVAK, Ahmet DOGAN, Yan W. ASMANN, Mark LIEBOW, Carrie A. THOMPSON, Stephen M. ANSELL, Thomas E. WITZIG, Hervé TILLE, Corinne HAIOUN, Thierry J. MOLINA, Henrik HJALGRIM, Bengt GLIMELIUS, Hans-Olov ADAMI, Göran ROOS, Paige M. BRACCI, Jacques RIBY, Martyn T. SMITH, Elizabeth A. HOLLY, Wendy COZEN, Patricia HARTGE, Lindsay M. MORTON, Richard K. SEVERSON, Lesley F. TINKER, Kari E. NORTH, Nikolaus BECKER, Yolanda BENAVENTE, Paolo BOFFETTA, Paul BRENNAN, Lenka FORETOVÁ, Marc MAYNADIE, Anthony STAINES, Tracy LIGHTFOOT, Simon CROUCH, Alex SMITH, Eve ROMAN, W. Ryan DIVER, Kenneth OFFIT, Andrew ZELENETZ, Robert J. KLEIN, Danylo J. VILLANO, Tongzhang ZHENG, Yawei ZHANG, Theodore R. HOLFORD, Jenny TURNER, Melissa C. SOUTHEY, Jacqueline CLAVEL, Jarmo VIRTAMO, Stephanie WEINSTEIN, Elio RIBOLI, Paolo VINEIS, Rudolph KAAKS, Heiner BOEING, Anne TJØNNELAND, Emanuele ANGELUCCI, Simonetta Di LOLLO, Marco RAIS, Immaculata De VIVO, Edward GIOVANNUCCI, Peter KRAFT, Jinyan HUANG, Baoshan MA, Yuanqing YE, Brian C. H. CHIU, Liming LIANG, Ju-Hyun PARK, Charles C. CHUNG, Dennis D. WEISENBURGER, Joseph F. FRAUMENI JR, Gilles SALLES, Martha GLENN, Lisa CANNON-ALBRIGHT, Karen CURTIN, Xifeng WU, Karin E. SMEDBY, Silvia de SANJOSE, Christine F. SKIBOLA, Sonja I. BERNDT, Brenda M. BIRMANN, Stephen J. CHANOCK a Nathaniel ROTHMAN. Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. Human molecular genetics. Oxford: Oxford University Press, 2016, roč. 25, č. 8, s. 1663-1676. ISSN 0964-6906. Dostupné z: https://dx.doi.org/10.1093/hmg/ddw027. |
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@article{1375496, author = {Machiela, Mitchell J. and Lan, Qing and Slager, Susan L. and Vermeulen, Roel C. H. and Teras, Lauren R. and Camp, Nicola J. and Cerhan, James R. and Spinelli, John J. and Wang, Sophia S. and Nieters, Alexandra and Vijai, Joseph and Yeager, Meredith and Wang, Zhaoming and Ghesquières, Hervé and McKay, James and Conde, Lucia and Bakker, Paul I. W. de and Cox, David G. and Burdett, Laurie and Monnereau, Alain and Flowers, Christopher R. and Roos, Anneclaire J. De and BrooksandWilson, Angela R. and Giles, Graham G. and Melbye, Mads and Gu, Jian and Jackson, Rebecca D. and Kane, Eleanor and Purdue, Mark P. and Vajdic, Claire M. and Albanes, Demetrius and Kelly, Rachel S. and Zucca, Mariagrazia and Bertrand, Kimberly A. and ZeleniuchandJacquotte, Anne and Lawrence, Charles and Hutchinson, Amy and Zhi, Degui and Habermann, Thomas M. and Link, Brian K. and Novak, Anne J. and Dogan, Ahmet and Asmann, Yan W. and Liebow, Mark and Thompson, Carrie A. and Ansell, Stephen M. and Witzig, Thomas E. and Tille, Hervé and Haioun, Corinne and Molina, Thierry J. and Hjalgrim, Henrik and Glimelius, Bengt and Adami, HansandOlov and Roos, Göran and Bracci, Paige M. and Riby, Jacques and Smith, Martyn T. and Holly, Elizabeth A. and Cozen, Wendy and Hartge, Patricia and Morton, Lindsay M. and Severson, Richard K. and Tinker, Lesley F. and North, Kari E. and Becker, Nikolaus and Benavente, Yolanda and Boffetta, Paolo and Brennan, Paul and Foretová, Lenka and Maynadie, Marc and Staines, Anthony and Lightfoot, Tracy and Crouch, Simon and Smith, Alex and Roman, Eve and Diver, W. Ryan and Offit, Kenneth and Zelenetz, Andrew and Klein, Robert J. and Villano, Danylo J. and Zheng, Tongzhang and Zhang, Yawei and Holford, Theodore R. and Turner, Jenny and Southey, Melissa C. and Clavel, Jacqueline and Virtamo, Jarmo and Weinstein, Stephanie and Riboli, Elio and Vineis, Paolo and Kaaks, Rudolph and Boeing, Heiner and Tjønneland, Anne and Angelucci, Emanuele and Lollo, Simonetta Di and Rais, Marco and Vivo, Immaculata De and Giovannucci, Edward and Kraft, Peter and Huang, Jinyan and Ma, Baoshan and Ye, Yuanqing and Chiu, Brian C. H. and Liang, Liming and Park, JuandHyun and Chung, Charles C. and Weisenburger, Dennis D. and Fraumeni Jr, Joseph F. and Salles, Gilles and Glenn, Martha and CannonandAlbright, Lisa and Curtin, Karen and Wu, Xifeng and Smedby, Karin E. and Sanjose, Silvia de and Skibola, Christine F. and Berndt, Sonja I. and Birmann, Brenda M. and Chanock, Stephen J. and Rothman, Nathaniel}, article_location = {Oxford}, article_number = {8}, doi = {http://dx.doi.org/10.1093/hmg/ddw027}, keywords = {GENOME-WIDE ASSOCIATION; CHRONIC LYMPHOCYTIC-LEUKEMIA; MENDELIAN RANDOMIZATION; EPIDEMIOLOGIC RESEARCH; SUSCEPTIBILITY LOCI; CANCER-RISK; HLA REGION; CLASSIFICATION; DYSFUNCTION; NEOPLASMS}, language = {eng}, issn = {0964-6906}, journal = {Human molecular genetics}, title = {Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes}, volume = {25}, year = {2016} }
TY - JOUR ID - 1375496 AU - Machiela, Mitchell J. - Lan, Qing - Slager, Susan L. - Vermeulen, Roel C. H. - Teras, Lauren R. - Camp, Nicola J. - Cerhan, James R. - Spinelli, John J. - Wang, Sophia S. - Nieters, Alexandra - Vijai, Joseph - Yeager, Meredith - Wang, Zhaoming - Ghesquières, Hervé - McKay, James - Conde, Lucia - Bakker, Paul I. W. de - Cox, David G. - Burdett, Laurie - Monnereau, Alain - Flowers, Christopher R. - Roos, Anneclaire J. De - Brooks-Wilson, Angela R. - Giles, Graham G. - Melbye, Mads - Gu, Jian - Jackson, Rebecca D. - Kane, Eleanor - Purdue, Mark P. - Vajdic, Claire M. - Albanes, Demetrius - Kelly, Rachel S. - Zucca, Mariagrazia - Bertrand, Kimberly A. - Zeleniuch-Jacquotte, Anne - Lawrence, Charles - Hutchinson, Amy - Zhi, Degui - Habermann, Thomas M. - Link, Brian K. - Novak, Anne J. - Dogan, Ahmet - Asmann, Yan W. - Liebow, Mark - Thompson, Carrie A. - Ansell, Stephen M. - Witzig, Thomas E. - Tille, Hervé - Haioun, Corinne - Molina, Thierry J. - Hjalgrim, Henrik - Glimelius, Bengt - Adami, Hans-Olov - Roos, Göran - Bracci, Paige M. - Riby, Jacques - Smith, Martyn T. - Holly, Elizabeth A. - Cozen, Wendy - Hartge, Patricia - Morton, Lindsay M. - Severson, Richard K. - Tinker, Lesley F. - North, Kari E. - Becker, Nikolaus - Benavente, Yolanda - Boffetta, Paolo - Brennan, Paul - Foretová, Lenka - Maynadie, Marc - Staines, Anthony - Lightfoot, Tracy - Crouch, Simon - Smith, Alex - Roman, Eve - Diver, W. Ryan - Offit, Kenneth - Zelenetz, Andrew - Klein, Robert J. - Villano, Danylo J. - Zheng, Tongzhang - Zhang, Yawei - Holford, Theodore R. - Turner, Jenny - Southey, Melissa C. - Clavel, Jacqueline - Virtamo, Jarmo - Weinstein, Stephanie - Riboli, Elio - Vineis, Paolo - Kaaks, Rudolph - Boeing, Heiner - Tjønneland, Anne - Angelucci, Emanuele - Lollo, Simonetta Di - Rais, Marco - Vivo, Immaculata De - Giovannucci, Edward - Kraft, Peter - Huang, Jinyan - Ma, Baoshan - Ye, Yuanqing - Chiu, Brian C. H. - Liang, Liming - Park, Ju-Hyun - Chung, Charles C. - Weisenburger, Dennis D. - Fraumeni Jr, Joseph F. - Salles, Gilles - Glenn, Martha - Cannon-Albright, Lisa - Curtin, Karen - Wu, Xifeng - Smedby, Karin E. - Sanjose, Silvia de - Skibola, Christine F. - Berndt, Sonja I. - Birmann, Brenda M. - Chanock, Stephen J. - Rothman, Nathaniel PY - 2016 TI - Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes JF - Human molecular genetics VL - 25 IS - 8 SP - 1663-1676 EP - 1663-1676 PB - Oxford University Press SN - 09646906 KW - GENOME-WIDE ASSOCIATION KW - CHRONIC LYMPHOCYTIC-LEUKEMIA KW - MENDELIAN RANDOMIZATION KW - EPIDEMIOLOGIC RESEARCH KW - SUSCEPTIBILITY LOCI KW - CANCER-RISK KW - HLA REGION KW - CLASSIFICATION KW - DYSFUNCTION KW - NEOPLASMS N2 - Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82, P-value = 8.5 x 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51, P-value = 4.0 x 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk. ER -
MACHIELA, Mitchell J., Qing LAN, Susan L. SLAGER, Roel C. H. VERMEULEN, Lauren R. TERAS, Nicola J. CAMP, James R. CERHAN, John J. SPINELLI, Sophia S. WANG, Alexandra NIETERS, Joseph VIJAI, Meredith YEAGER, Zhaoming WANG, Hervé GHESQUIÈRES, James MCKAY, Lucia CONDE, Paul I. W. de BAKKER, David G. COX, Laurie BURDETT, Alain MONNEREAU, Christopher R. FLOWERS, Anneclaire J. De ROOS, Angela R. BROOKS-WILSON, Graham G. GILES, Mads MELBYE, Jian GU, Rebecca D. JACKSON, Eleanor KANE, Mark P. PURDUE, Claire M. VAJDIC, Demetrius ALBANES, Rachel S. KELLY, Mariagrazia ZUCCA, Kimberly A. BERTRAND, Anne ZELENIUCH-JACQUOTTE, Charles LAWRENCE, Amy HUTCHINSON, Degui ZHI, Thomas M. HABERMANN, Brian K. LINK, Anne J. NOVAK, Ahmet DOGAN, Yan W. ASMANN, Mark LIEBOW, Carrie A. THOMPSON, Stephen M. ANSELL, Thomas E. WITZIG, Hervé TILLE, Corinne HAIOUN, Thierry J. MOLINA, Henrik HJALGRIM, Bengt GLIMELIUS, Hans-Olov ADAMI, Göran ROOS, Paige M. BRACCI, Jacques RIBY, Martyn T. SMITH, Elizabeth A. HOLLY, Wendy COZEN, Patricia HARTGE, Lindsay M. MORTON, Richard K. SEVERSON, Lesley F. TINKER, Kari E. NORTH, Nikolaus BECKER, Yolanda BENAVENTE, Paolo BOFFETTA, Paul BRENNAN, Lenka FORETOVÁ, Marc MAYNADIE, Anthony STAINES, Tracy LIGHTFOOT, Simon CROUCH, Alex SMITH, Eve ROMAN, W. Ryan DIVER, Kenneth OFFIT, Andrew ZELENETZ, Robert J. KLEIN, Danylo J. VILLANO, Tongzhang ZHENG, Yawei ZHANG, Theodore R. HOLFORD, Jenny TURNER, Melissa C. SOUTHEY, Jacqueline CLAVEL, Jarmo VIRTAMO, Stephanie WEINSTEIN, Elio RIBOLI, Paolo VINEIS, Rudolph KAAKS, Heiner BOEING, Anne TJØNNELAND, Emanuele ANGELUCCI, Simonetta Di LOLLO, Marco RAIS, Immaculata De VIVO, Edward GIOVANNUCCI, Peter KRAFT, Jinyan HUANG, Baoshan MA, Yuanqing YE, Brian C. H. CHIU, Liming LIANG, Ju-Hyun PARK, Charles C. CHUNG, Dennis D. WEISENBURGER, Joseph F. FRAUMENI JR, Gilles SALLES, Martha GLENN, Lisa CANNON-ALBRIGHT, Karen CURTIN, Xifeng WU, Karin E. SMEDBY, Silvia de SANJOSE, Christine F. SKIBOLA, Sonja I. BERNDT, Brenda M. BIRMANN, Stephen J. CHANOCK a Nathaniel ROTHMAN. Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. \textit{Human molecular genetics}. Oxford: Oxford University Press, 2016, roč.~25, č.~8, s.~1663-1676. ISSN~0964-6906. Dostupné z: https://dx.doi.org/10.1093/hmg/ddw027.
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