TDM1 Regulation Determines the Number of Meiotic Divisions

J 2016

TDM1 Regulation Determines the Number of Meiotic Divisions

CIFUENTES, Marta, Sylvie JOLIVET, Laurence CROMER, Hirofumi HARASHIMA, Petra BULANKOVA et. al.

Basic information

Original name

TDM1 Regulation Determines the Number of Meiotic Divisions

Authors

CIFUENTES, Marta (250 France), Sylvie JOLIVET (250 France), Laurence CROMER (250 France), Hirofumi HARASHIMA (392 Japan), Petra BULANKOVA (40 Austria), Charlotte RENNE (250 France), Wayne CRISMANI (250 France), Yuko NOMURA (392 Japan), Hirofumi NAKAGAMI (392 Japan), Keiko SUGIMOTO (392 Japan), Arp SCHNITTGER (276 Germany), Karel ŘÍHA (203 Czech Republic, guarantor, belonging to the institution) and Raphael MERCIER (250 France)

Edition

PLOS GENETICS, SAN FRANCISCO, PUBLIC LIBRARY SCIENCE, 2016, 1553-7404

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.100

RIV identification code

RIV/00216224:14740/16:00088769

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1371/journal.pgen.1005856

UT WoS

000372554100039

Keywords in English

ANAPHASE-PROMOTING COMPLEX/CYCLOSOME; MEIOSIS-II TRANSITION; FISSION YEAST; ARABIDOPSIS; CYCLIN; PROTEINS; APC/C; PROGRESSION; EXPRESSION; INTERKINESIS

Abstract

V originále

Cell cycle control must be modified at meiosis to allow two divisions to follow a single round of DNA replication, resulting in ploidy reduction. The mechanisms that ensure meiosis termination at the end of the second and not at the end of first division are poorly understood. We show here that Arabidopsis thaliana TDM1, which has been previously shown to be essential for meiotic termination, interacts directly with the Anaphase-Promoting Complex. Further, mutations in TDM1 in a conserved putative Cyclin-Dependant Kinase (CDK) phosphorylation site (T16-P17) dominantly provoked premature meiosis termination after the first division, and the production of diploid spores and gametes. The CDKA; 1-CYCA1.2/TAM complex, which is required to prevent premature meiotic exit, phosphorylated TDM1 at T16 in vitro. Finally, while CYCA1;2/TAM was previously shown to be expressed only at meiosis I, TDM1 is present throughout meiosis. These data, together with epistasis analysis, lead us to propose that TDM1 is an APC/C component whose function is to ensure meiosis termination at the end of meiosis II, and whose activity is inhibited at meiosis I by CDKA; 1-TAM-mediated phosphorylation to prevent premature meiotic exit. This provides a molecular mechanism for the differential decision of performing an additional round of division, or not, at the end of meiosis I and II, respectively.

Links

GA14-22346S, research and development project

Name: Funkce TDM1 proteinu v meiόze

Investor: Czech Science Foundation

Citovat

CIFUENTES, Marta, Sylvie JOLIVET, Laurence CROMER, Hirofumi HARASHIMA, Petra BULANKOVA, Charlotte RENNE, Wayne CRISMANI, Yuko NOMURA, Hirofumi NAKAGAMI, Keiko SUGIMOTO, Arp SCHNITTGER, Karel ŘÍHA and Raphael MERCIER. TDM1 Regulation Determines the Number of Meiotic Divisions. PLOS GENETICS. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2016, vol. 12, No 2, p. nestránkováno, 22 pp. ISSN 1553-7404. Available from: https://dx.doi.org/10.1371/journal.pgen.1005856.

@article{1375508,
   author = {Cifuentes, Marta and Jolivet, Sylvie and Cromer, Laurence and Harashima, Hirofumi and Bulankova, Petra and Renne, Charlotte and Crismani, Wayne and Nomura, Yuko and Nakagami, Hirofumi and Sugimoto, Keiko and Schnittger, Arp and Říha, Karel and Mercier, Raphael},
   article_location = {SAN FRANCISCO},
   article_number = {2},
   doi = {http://dx.doi.org/10.1371/journal.pgen.1005856},
   keywords = {ANAPHASE-PROMOTING COMPLEX/CYCLOSOME; MEIOSIS-II TRANSITION; FISSION YEAST; ARABIDOPSIS; CYCLIN; PROTEINS; APC/C; PROGRESSION; EXPRESSION; INTERKINESIS},
   language = {eng},
   issn = {1553-7404},
   journal = {PLOS GENETICS},
   title = {TDM1 Regulation Determines the Number of Meiotic Divisions},
   url = {http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005856},
   volume = {12},
   year = {2016}
}

TY  - JOUR
ID  - 1375508
AU  - Cifuentes, Marta - Jolivet, Sylvie - Cromer, Laurence - Harashima, Hirofumi - Bulankova, Petra - Renne, Charlotte - Crismani, Wayne - Nomura, Yuko - Nakagami, Hirofumi - Sugimoto, Keiko - Schnittger, Arp - Říha, Karel - Mercier, Raphael
PY  - 2016
TI  - TDM1 Regulation Determines the Number of Meiotic Divisions
JF  - PLOS GENETICS
VL  - 12
IS  - 2
SP  - nestránkováno
EP  - nestránkováno
PB  - PUBLIC LIBRARY SCIENCE
SN  - 15537404
KW  - ANAPHASE-PROMOTING COMPLEX/CYCLOSOME
KW  - MEIOSIS-II TRANSITION
KW  - FISSION YEAST
KW  - ARABIDOPSIS
KW  - CYCLIN
KW  - PROTEINS
KW  - APC/C
KW  - PROGRESSION
KW  - EXPRESSION
KW  - INTERKINESIS
UR  - http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005856
L2  - http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005856
N2  - Cell cycle control must be modified at meiosis to allow two divisions to follow a single round of DNA replication, resulting in ploidy reduction. The mechanisms that ensure meiosis termination at the end of the second and not at the end of first division are poorly understood. We show here that Arabidopsis thaliana TDM1, which has been previously shown to be essential for meiotic termination, interacts directly with the Anaphase-Promoting Complex. Further, mutations in TDM1 in a conserved putative Cyclin-Dependant Kinase (CDK) phosphorylation site (T16-P17) dominantly provoked premature meiosis termination after the first division, and the production of diploid spores and gametes. The CDKA; 1-CYCA1.2/TAM complex, which is required to prevent premature meiotic exit, phosphorylated TDM1 at T16 in vitro. Finally, while CYCA1;2/TAM was previously shown to be expressed only at meiosis I, TDM1 is present throughout meiosis. These data, together with epistasis analysis, lead us to propose that TDM1 is an APC/C component whose function is to ensure meiosis termination at the end of meiosis II, and whose activity is inhibited at meiosis I by CDKA; 1-TAM-mediated phosphorylation to prevent premature meiotic exit. This provides a molecular mechanism for the differential decision of performing an additional round of division, or not, at the end of meiosis I and II, respectively.
ER  -

CIFUENTES, Marta, Sylvie JOLIVET, Laurence CROMER, Hirofumi HARASHIMA, Petra BULANKOVA, Charlotte RENNE, Wayne CRISMANI, Yuko NOMURA, Hirofumi NAKAGAMI, Keiko SUGIMOTO, Arp SCHNITTGER, Karel ŘÍHA and Raphael MERCIER. TDM1 Regulation Determines the Number of Meiotic Divisions. \textit{PLOS GENETICS}. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2016, vol.~12, No~2, p.~nestránkováno, 22 pp. ISSN~1553-7404. Available from: https://dx.doi.org/10.1371/journal.pgen.1005856.

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