| BLAŽEK, Dalibor, Fernando TEQUE, Carl MACKEWICZ, Matija PETERLIN and Jay A. LEVY. The CD8+cell non-cytotoxic antiviral response affects RNA polymerase II-mediated human immunodeficiency virus transcription in infected CD4+cells. Journal of General Virology. Reading: Society of General Microbiology, 2016, vol. 97, January, p. 220-224. ISSN 0022-1317. Available from: https://dx.doi.org/10.1099/jgv.0.000326. |
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@article{1375560,
author = {Blažek, Dalibor and Teque, Fernando and Mackewicz, Carl and Peterlin, Matija and Levy, Jay A.},
article_location = {Reading},
article_number = {January},
doi = {http://dx.doi.org/10.1099/jgv.0.000326},
keywords = {ANTI-HIV RESPONSE; CD8(+) T-CELLS; P-TEFB; FACTOR CAF; REPLICATION; INHIBITION; PATHOGENESIS; LYMPHOCYTES; ELONGATION; EXPRESSION},
language = {eng},
issn = {0022-1317},
journal = {Journal of General Virology},
title = {The CD8+cell non-cytotoxic antiviral response affects RNA polymerase II-mediated human immunodeficiency virus transcription in infected CD4+cells},
url = {http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000326},
volume = {97},
year = {2016}
}
TY - JOUR
ID - 1375560
AU - Blažek, Dalibor - Teque, Fernando - Mackewicz, Carl - Peterlin, Matija - Levy, Jay A.
PY - 2016
TI - The CD8+cell non-cytotoxic antiviral response affects RNA polymerase II-mediated human immunodeficiency virus transcription in infected CD4+cells
JF - Journal of General Virology
VL - 97
IS - January
SP - 220-224
EP - 220-224
PB - Society of General Microbiology
SN - 00221317
KW - ANTI-HIV RESPONSE
KW - CD8(+) T-CELLS
KW - P-TEFB
KW - FACTOR CAF
KW - REPLICATION
KW - INHIBITION
KW - PATHOGENESIS
KW - LYMPHOCYTES
KW - ELONGATION
KW - EXPRESSION
UR - http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000326
L2 - http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000326
N2 - A CD8+ cell non-cytotoxic antiviral response (CNAR), mediated by a CD8+ cell antiviral factor (CAF), is associated with a long-term healthy state in human immunodeficiency virus (HIV) infection. CNAR/CAF reduces viral transcription without a known effect on specific viral sequences in the HIV genome. In studies to define the mechanism involved in the block in viral transcription, we now report that transcription from the HIV-LTR reporter is reduced in infected CD4+ cells upon treatment with CAF. In agreement with this observation, the amount of RNA polymerase II (RNAPII) on the HIV promoter and other viral regions was strongly diminished in HIV-infected CD4+ cells co-cultivated with CNAR-expressing CD8+ cells. These results demonstrate further that CNAR/CAF has a specific role in regulating HIV transcription and a step during the preinitiation complex assembly appears to be sensitive to CNAR/CAF.
ER -
BLAŽEK, Dalibor, Fernando TEQUE, Carl MACKEWICZ, Matija PETERLIN and Jay A. LEVY. The CD8+cell non-cytotoxic antiviral response affects RNA polymerase II-mediated human immunodeficiency virus transcription in infected CD4+cells. \textit{Journal of General Virology}. Reading: Society of General Microbiology, 2016, vol.~97, January, p.~220-224. ISSN~0022-1317. Available from: https://dx.doi.org/10.1099/jgv.0.000326.
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