| LUJAN-BARROSO, Leila, Wei ZHANG, Sara H. OLSON, Yu-Tang GAO, Herbert YU, Peter A. BAGHURST, Paige M. BRACCI, Bas H. BUENO-DE-MESQUITA, Lenka FORETOVÁ, Steven GALLINGER, Ivana HOLCATOVA, Vladimir JANOUT, Bu-Tian JI, Robert C. KURTZ, Carlo LA VECCHIA, Pagona LAGIOU, Donghui LI, Anthony B. MILLER, Diego SERRAINO, Witold ZATONSKI, Harvey A. RISCH a Eric J. DUELL. Menstrual and Reproductive Factors, Hormone Use, and Risk of Pancreatic Cancer: Analysis From the International Pancreatic Cancer Case-Control Consortium (PanC4). Pancreas. Philadelphia: Lippincott Williams & Wilkins, 2016, roč. 45, č. 10, s. 1401-1410. ISSN 0885-3177. Dostupné z: https://dx.doi.org/10.1097/MPA.0000000000000635. |
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@article{1375573,
author = {LujanandBarroso, Leila and Zhang, Wei and Olson, Sara H. and Gao, YuandTang and Yu, Herbert and Baghurst, Peter A. and Bracci, Paige M. and BuenoanddeandMesquita, Bas H. and Foretová, Lenka and Gallinger, Steven and Holcatova, Ivana and Janout, Vladimir and Ji, BuandTian and Kurtz, Robert C. and La Vecchia, Carlo and Lagiou, Pagona and Li, Donghui and Miller, Anthony B. and Serraino, Diego and Zatonski, Witold and Risch, Harvey A. and Duell, Eric J.},
article_location = {Philadelphia},
article_number = {10},
doi = {http://dx.doi.org/10.1097/MPA.0000000000000635},
keywords = {pancreatic cancer; menstrual and reproductive factors; exogenous hormones; hysterectomy; consortium},
language = {eng},
issn = {0885-3177},
journal = {Pancreas},
title = {Menstrual and Reproductive Factors, Hormone Use, and Risk of Pancreatic Cancer: Analysis From the International Pancreatic Cancer Case-Control Consortium (PanC4)},
volume = {45},
year = {2016}
}
TY - JOUR
ID - 1375573
AU - Lujan-Barroso, Leila - Zhang, Wei - Olson, Sara H. - Gao, Yu-Tang - Yu, Herbert - Baghurst, Peter A. - Bracci, Paige M. - Bueno-de-Mesquita, Bas H. - Foretová, Lenka - Gallinger, Steven - Holcatova, Ivana - Janout, Vladimir - Ji, Bu-Tian - Kurtz, Robert C. - La Vecchia, Carlo - Lagiou, Pagona - Li, Donghui - Miller, Anthony B. - Serraino, Diego - Zatonski, Witold - Risch, Harvey A. - Duell, Eric J.
PY - 2016
TI - Menstrual and Reproductive Factors, Hormone Use, and Risk of Pancreatic Cancer: Analysis From the International Pancreatic Cancer Case-Control Consortium (PanC4)
JF - Pancreas
VL - 45
IS - 10
SP - 1401-1410
EP - 1401-1410
PB - Lippincott Williams & Wilkins
SN - 08853177
KW - pancreatic cancer
KW - menstrual and reproductive factors
KW - exogenous hormones
KW - hysterectomy
KW - consortium
N2 - Objectives We aimed to evaluate the relation between menstrual and reproductive factors, exogenous hormones, and risk of pancreatic cancer (PC). Methods Eleven case-control studies within the International Pancreatic Cancer Case-control Consortium took part in the present study, including in total 2838 case and 4748 control women. Pooled estimates of odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using a 2-step logistic regression model and adjusting for relevant covariates. Results An inverse OR was observed in women who reported having had hysterectomy (ORyesvs.no, 0.78; 95% CI, 0.67-0.91), remaining significant in postmenopausal women and never-smoking women, adjusted for potential PC confounders. A mutually adjusted model with the joint effect for hormone replacement therapy (HRT) and hysterectomy showed significant inverse associations with PC in women who reported having had hysterectomy with HRT use (OR, 0.64; 95% CI, 0.48-0.84). Conclusions Our large pooled analysis suggests that women who have had a hysterectomy may have reduced risk of PC. However, we cannot rule out that the reduced risk could be due to factors or indications for having had a hysterectomy. Further investigation of risk according to HRT use and reason for hysterectomy may be necessary.
ER -
LUJAN-BARROSO, Leila, Wei ZHANG, Sara H. OLSON, Yu-Tang GAO, Herbert YU, Peter A. BAGHURST, Paige M. BRACCI, Bas H. BUENO-DE-MESQUITA, Lenka FORETOVÁ, Steven GALLINGER, Ivana HOLCATOVA, Vladimir JANOUT, Bu-Tian JI, Robert C. KURTZ, Carlo LA VECCHIA, Pagona LAGIOU, Donghui LI, Anthony B. MILLER, Diego SERRAINO, Witold ZATONSKI, Harvey A. RISCH a Eric J. DUELL. Menstrual and Reproductive Factors, Hormone Use, and Risk of Pancreatic Cancer: Analysis From the International Pancreatic Cancer Case-Control Consortium (PanC4). \textit{Pancreas}. Philadelphia: Lippincott Williams \&{} Wilkins, 2016, roč.~45, č.~10, s.~1401-1410. ISSN~0885-3177. Dostupné z: https://dx.doi.org/10.1097/MPA.0000000000000635.
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