DAVIS, Ann, Meng-Hua TAO, Jia CHEN, Ghislaine SCELO, Vladimir BENCKO, Eleonora FABIANOVA, Lenka FORETOVÁ, Vladimir JANOUT, Jolanta LISSOWSKA, Dana MATES, Ioan N MATES, Peter RUDNAI, David ZARIDZE and Paolo BOFFETTA. No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe. European Journal of Cancer Prevention. Philadelphia: Lippincott Williams & Wilkins, vol. 27, No 1, p. 1-5. ISSN 0959-8278. doi:10.1097/CEJ.0000000000000244. 2018.
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Basic information
Original name No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe
Authors DAVIS, Ann (840 United States of America), Meng-Hua TAO (840 United States of America, guarantor), Jia CHEN (840 United States of America), Ghislaine SCELO (250 France), Vladimir BENCKO (203 Czech Republic), Eleonora FABIANOVA (703 Slovakia), Lenka FORETOVÁ (203 Czech Republic, belonging to the institution), Vladimir JANOUT (203 Czech Republic), Jolanta LISSOWSKA (616 Poland), Dana MATES (642 Romania), Ioan N MATES (642 Romania), Peter RUDNAI (348 Hungary), David ZARIDZE (643 Russian Federation) and Paolo BOFFETTA (840 United States of America).
Edition European Journal of Cancer Prevention, Philadelphia, Lippincott Williams & Wilkins, 2018, 0959-8278.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30204 Oncology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.330
RIV identification code RIV/00216224:14110/18:00101981
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1097/CEJ.0000000000000244
UT WoS 000417289000001
Keywords in English epidemiology; global methylation; lung cancer; never-smoking women
Tags 14110811, EL OK, rivok
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 21/3/2019 12:06.
Abstract
Alterations in global DNA methylation have been suggested to play an important role in cancer development. We evaluated the association of global DNA methylation in peripheral blood with the risk of lung cancer in nonsmoking women from six countries in Central and Eastern Europe. This multicenter case–control study included primary, incident lung cancer cases diagnosed from 1998 to 2001 and controls frequency-matched for geographic area, sex, and age. Global methylation was assessed in peripheral blood DNA from 83 nonsmoking female cases and 181 nonsmoking female controls using the luminometric methylation assay (LUMA). Unconditional logistic regression models were used to estimate associations between DNA methylation in the blood and the risk of lung cancer. LUMA methylation level was not associated with the risk of lung cancer in nonsmoking women. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. In our study of nonsmoking women, the LUMA methylation level in peripheral blood was not associated with the risk of lung cancer. Our findings do not support an association of global blood DNA methylation with the risk of lung cancer in nonsmoking women.
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