No association between global DNA methylation in peripheral
blood and lung cancer risk in nonsmoking women: results from a
multicenter study in Eastern and Central Europe

J 2018

No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe

DAVIS, Ann, Meng-Hua TAO, Jia CHEN, Ghislaine SCELO, Vladimir BENCKO et. al.

Basic information

Original name

No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe

Authors

DAVIS, Ann (840 United States of America), Meng-Hua TAO (840 United States of America, guarantor), Jia CHEN (840 United States of America), Ghislaine SCELO (250 France), Vladimir BENCKO (203 Czech Republic), Eleonora FABIANOVA (703 Slovakia), Lenka FORETOVÁ (203 Czech Republic, belonging to the institution), Vladimir JANOUT (203 Czech Republic), Jolanta LISSOWSKA (616 Poland), Dana MATES (642 Romania), Ioan N MATES (642 Romania), Peter RUDNAI (348 Hungary), David ZARIDZE (643 Russian Federation) and Paolo BOFFETTA (840 United States of America)

Edition

European Journal of Cancer Prevention, Philadelphia, Lippincott Williams & Wilkins, 2018, 0959-8278

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.330

RIV identification code

RIV/00216224:14110/18:00101981

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1097/CEJ.0000000000000244

UT WoS

000417289000001

Keywords in English

epidemiology; global methylation; lung cancer; never-smoking women

Abstract

V originále

Alterations in global DNA methylation have been suggested to play an important role in cancer development. We evaluated the association of global DNA methylation in peripheral blood with the risk of lung cancer in nonsmoking women from six countries in Central and Eastern Europe. This multicenter case–control study included primary, incident lung cancer cases diagnosed from 1998 to 2001 and controls frequency-matched for geographic area, sex, and age. Global methylation was assessed in peripheral blood DNA from 83 nonsmoking female cases and 181 nonsmoking female controls using the luminometric methylation assay (LUMA). Unconditional logistic regression models were used to estimate associations between DNA methylation in the blood and the risk of lung cancer. LUMA methylation level was not associated with the risk of lung cancer in nonsmoking women. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. In our study of nonsmoking women, the LUMA methylation level in peripheral blood was not associated with the risk of lung cancer. Our findings do not support an association of global blood DNA methylation with the risk of lung cancer in nonsmoking women.

Citovat

DAVIS, Ann, Meng-Hua TAO, Jia CHEN, Ghislaine SCELO, Vladimir BENCKO, Eleonora FABIANOVA, Lenka FORETOVÁ, Vladimir JANOUT, Jolanta LISSOWSKA, Dana MATES, Ioan N MATES, Peter RUDNAI, David ZARIDZE and Paolo BOFFETTA. No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe. European Journal of Cancer Prevention. Philadelphia: Lippincott Williams & Wilkins, 2018, vol. 27, No 1, p. 1-5. ISSN 0959-8278. Available from: https://dx.doi.org/10.1097/CEJ.0000000000000244.

@article{1375586,
   author = {Davis, Ann and Tao, MengandHua and Chen, Jia and Scelo, Ghislaine and Bencko, Vladimir and Fabianova, Eleonora and Foretová, Lenka and Janout, Vladimir and Lissowska, Jolanta and Mates, Dana and Mates, Ioan N and Rudnai, Peter and Zaridze, David and Boffetta, Paolo},
   article_location = {Philadelphia},
   article_number = {1},
   doi = {http://dx.doi.org/10.1097/CEJ.0000000000000244},
   keywords = {epidemiology; global methylation; lung cancer; never-smoking women},
   language = {eng},
   issn = {0959-8278},
   journal = {European Journal of Cancer Prevention},
   title = {No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe},
   volume = {27},
   year = {2018}
}

TY  - JOUR
ID  - 1375586
AU  - Davis, Ann - Tao, Meng-Hua - Chen, Jia - Scelo, Ghislaine - Bencko, Vladimir - Fabianova, Eleonora - Foretová, Lenka - Janout, Vladimir - Lissowska, Jolanta - Mates, Dana - Mates, Ioan N - Rudnai, Peter - Zaridze, David - Boffetta, Paolo
PY  - 2018
TI  - No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe
JF  - European Journal of Cancer Prevention
VL  - 27
IS  - 1
SP  - 1-5
EP  - 1-5
PB  - Lippincott Williams & Wilkins
SN  - 09598278
KW  - epidemiology
KW  - global methylation
KW  - lung cancer
KW  - never-smoking women
N2  - Alterations in global DNA methylation have been suggested to play an important role in cancer development. We evaluated the association of global DNA methylation in peripheral blood with the risk of lung cancer in nonsmoking women from six countries in Central and Eastern Europe. This multicenter case–control study included primary, incident lung cancer cases diagnosed from 1998 to 2001 and controls frequency-matched for geographic area, sex, and age. Global methylation was assessed in peripheral blood DNA from 83 nonsmoking female cases and 181 nonsmoking female controls using the luminometric methylation assay (LUMA). Unconditional logistic regression models were used to estimate associations between DNA methylation in the blood and the risk of lung cancer. LUMA methylation level was not associated with the risk of lung cancer in nonsmoking women. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. In our study of nonsmoking women, the LUMA methylation level in peripheral blood was not associated with the risk of lung cancer. Our findings do not support an association of global blood DNA methylation with the risk of lung cancer in nonsmoking women.
ER  -

DAVIS, Ann, Meng-Hua TAO, Jia CHEN, Ghislaine SCELO, Vladimir BENCKO, Eleonora FABIANOVA, Lenka FORETOVÁ, Vladimir JANOUT, Jolanta LISSOWSKA, Dana MATES, Ioan N MATES, Peter RUDNAI, David ZARIDZE and Paolo BOFFETTA. No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe. \textit{European Journal of Cancer Prevention}. Philadelphia: Lippincott Williams \&{} Wilkins, 2018, vol.~27, No~1, p.~1-5. ISSN~0959-8278. Available from: https://dx.doi.org/10.1097/CEJ.0000000000000244.

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