Human Treponema pallidum 11q/j isolate belongs to subsp.
endemicum but contains two loci with a sequence in TP0548 and
TP0488 similar to subsp. pertenue and subsp. pallidum,
respectively

J 2017

Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively

MIKALOVÁ, Lenka, Michal STROUHAL, Jan OPPELT, Philippe Alain GRANGE, Michel JANIER et. al.

Basic information

Original name

Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively

Authors

MIKALOVÁ, Lenka (203 Czech Republic, belonging to the institution), Michal STROUHAL (203 Czech Republic, belonging to the institution), Jan OPPELT (203 Czech Republic, belonging to the institution), Philippe Alain GRANGE (250 France), Michel JANIER (250 France), Nadjet BENHADDOU (250 France), Nicolas DUPIN (250 France) and David ŠMAJS (203 Czech Republic, guarantor, belonging to the institution)

Edition

PLoS neglected tropical diseases, San Francisco, Public Library of Science, 2017, 1935-2735

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.367

RIV identification code

RIV/00216224:14110/17:00094671

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1371/journal.pntd.0005434

UT WoS

000402251300033

Keywords in English

Treponema pallidum

Abstract

V originále

The TEN 11q/j isolate was characterized using nested PCR followed by Sanger sequencing and/or direct Illumina sequencing. Altogether, 44 chromosomal regions were analyzed. Overall, the 11q/j isolate clustered with TEN strains Bosnia A and Iraq B as expected from previous TEN classification of the 11q/j isolate. However, the 11q/j sequence in a 505 bp-long region at the TP0488 locus was similar to Treponema pallidum subsp. pallidum (TPA) strains, but not to TEN Bosnia A and Iraq B sequences, suggesting a recombination event at this locus. Similarly, the 11q/j sequence in a 613 bp-long region at the TP0548 locus was similar to Treponema pallidum subsp. pertenue (TPE) strains, but not to TEN sequences.

Links

GAP302/12/0574, research and development project

Name: Celogenomové sekvencování v analýze genomů a transkriptomů patogenních bakterií rodu Treponema

Investor: Czech Science Foundation

GA17-25455S, research and development project

Name: Studium genomů patogenních treponem na základě analýzy jednotlivých buněk

Investor: Czech Science Foundation

GP14-29596P, research and development project

Name: Genomová variabilita treponem během experimentální infekce

Investor: Czech Science Foundation

ROZV/20/LF/2015, interní kód MU

Name: LF - Příspěvek IP 2015

Investor: Ministry of Education, Youth and Sports of the CR

ROZV/24/LF/2016, interní kód MU

Name: LF - Příspěvek IP 2016

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

MIKALOVÁ, Lenka, Michal STROUHAL, Jan OPPELT, Philippe Alain GRANGE, Michel JANIER, Nadjet BENHADDOU, Nicolas DUPIN and David ŠMAJS. Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively. PLoS neglected tropical diseases. San Francisco: Public Library of Science, 2017, vol. 11, No 3, p. 1-14. ISSN 1935-2735. Available from: https://dx.doi.org/10.1371/journal.pntd.0005434.

@article{1375593,
   author = {Mikalová, Lenka and Strouhal, Michal and Oppelt, Jan and Grange, Philippe Alain and Janier, Michel and Benhaddou, Nadjet and Dupin, Nicolas and Šmajs, David},
   article_location = {San Francisco},
   article_number = {3},
   doi = {http://dx.doi.org/10.1371/journal.pntd.0005434},
   keywords = {Treponema pallidum},
   language = {eng},
   issn = {1935-2735},
   journal = {PLoS neglected tropical diseases},
   title = {Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively},
   url = {http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005434},
   volume = {11},
   year = {2017}
}

TY  - JOUR
ID  - 1375593
AU  - Mikalová, Lenka - Strouhal, Michal - Oppelt, Jan - Grange, Philippe Alain - Janier, Michel - Benhaddou, Nadjet - Dupin, Nicolas - Šmajs, David
PY  - 2017
TI  - Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively
JF  - PLoS neglected tropical diseases
VL  - 11
IS  - 3
SP  - 1-14
EP  - 1-14
PB  - Public Library of Science
SN  - 19352735
KW  - Treponema pallidum
UR  - http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005434
N2  - The TEN 11q/j isolate was characterized using nested PCR followed by Sanger sequencing and/or direct Illumina sequencing. Altogether, 44 chromosomal regions were analyzed. Overall, the 11q/j isolate clustered with TEN strains Bosnia A and Iraq B as expected from previous TEN classification of the 11q/j isolate. However, the 11q/j sequence in a 505 bp-long region at the TP0488 locus was similar to Treponema pallidum subsp. pallidum (TPA) strains, but not to TEN Bosnia A and Iraq B sequences, suggesting a recombination event at this locus. Similarly, the 11q/j sequence in a 613 bp-long region at the TP0548 locus was similar to Treponema pallidum subsp. pertenue (TPE) strains, but not to TEN sequences.
ER  -

MIKALOVÁ, Lenka, Michal STROUHAL, Jan OPPELT, Philippe Alain GRANGE, Michel JANIER, Nadjet BENHADDOU, Nicolas DUPIN and David ŠMAJS. Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively. \textit{PLoS neglected tropical diseases}. San Francisco: Public Library of Science, 2017, vol.~11, No~3, p.~1-14. ISSN~1935-2735. Available from: https://dx.doi.org/10.1371/journal.pntd.0005434.

Detailed Information on Publication Record