ŠERÝ, Omar, Lýdia HLINECKÁ, Jana POVOVA, Ondřej BONCZEK, Tomáš ZEMAN, Vladimír JANOUT, Petr AMBROZ, Naim Akhtar KHAN a Vladimír Josef BALCAR. Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index. Journal of the neurological sciences. Netherlands: Amsterdam : Elsevier, roč. 362, March, s. 27-32. ISSN 0022-510X. doi:10.1016/j.jns.2016.01.022. 2016.
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Základní údaje
Originální název Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index
Autoři ŠERÝ, Omar (203 Česká republika, garant, domácí), Lýdia HLINECKÁ (203 Česká republika, domácí), Jana POVOVA (203 Česká republika), Ondřej BONCZEK (203 Česká republika, domácí), Tomáš ZEMAN (203 Česká republika, domácí), Vladimír JANOUT (203 Česká republika), Petr AMBROZ (203 Česká republika), Naim Akhtar KHAN (250 Francie) a Vladimír Josef BALCAR (36 Austrálie).
Vydání Journal of the neurological sciences, Netherlands, Amsterdam : Elsevier, 2016, 0022-510X.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30000 3. Medical and Health Sciences
Stát vydavatele Nizozemské království
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 2.295
Kód RIV RIV/00216224:14310/16:00088953
Organizační jednotka Přírodovědecká fakulta
Doi http://dx.doi.org/10.1016/j.jns.2016.01.022
UT WoS 000372558400005
Klíčová slova anglicky Alzheimer's disease; Arachidonic acid; Association; Caffeic acid; Curcumin; FLAP; Genetics; Inflammation; Leukotrienes; Polymorphism
Štítky AKR, rivok
Změnil Změnila: Ing. Andrea Mikešková, učo 137293. Změněno: 30. 3. 2017 10:21.
Anotace
Dementias of old age, in particular Alzheimer's disease (AD), pose a growing threat to the longevity and quality of life of individuals as well as whole societies world-wide. The risk factors are both genetic and environmental (life-style) and there is an overlap with similar factors predisposing to cardiovascular diseases (CVD). Using a case-control genetic approach, we have identified a SNP (rs10507391) in ALOX5 gene, previously associated with an increased risk of stroke, as a novel genetic risk factor for AD. ALOX5 gene encodes a 5-lipoxygenase (5-LO) activating protein (FLAP), a crucial component of the arachidonic acid/leukotriene inflammatory cascade. A-allele of rs4769874 polymorphism increases the risk of AD 1.41-fold (p = 0.0001), while AA genotype does so 1.79-fold (p = 0.0001). In addition, GG genotype of rs4769874 polymorphism is associated with a modest increase in body mass index (BMI). We discuss potential biochemical mechanisms linking the SNP to AD and suggest possible preventive pharmacotherapies some of which are based on commonly available natural products. Finally, we set the newly identified AD risk factors into a broader context of similar CVD risk factors to generate a more comprehensive picture of interacting genetics and life-style habits potentially leading to the deteriorating mental health in the old age.
Návaznosti
NT11152, projekt VaVNázev: Epidemiologie a genetika Alzheimerovy choroby
VytisknoutZobrazeno: 29. 3. 2024 03:26