Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is
associated with Alzheimer's disease and body mass index

J 2016

Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index

ŠERÝ, Omar, Lýdia HLINECKÁ, Jana POVOVA, Ondřej BONCZEK, Tomáš ZEMAN et. al.

Basic information

Original name

Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index

Authors

ŠERÝ, Omar (203 Czech Republic, guarantor, belonging to the institution), Lýdia HLINECKÁ (203 Czech Republic, belonging to the institution), Jana POVOVA (203 Czech Republic), Ondřej BONCZEK (203 Czech Republic, belonging to the institution), Tomáš ZEMAN (203 Czech Republic, belonging to the institution), Vladimír JANOUT (203 Czech Republic), Petr AMBROZ (203 Czech Republic), Naim Akhtar KHAN (250 France) and Vladimír Josef BALCAR (36 Australia)

Edition

Journal of the neurological sciences, Netherlands, Amsterdam : Elsevier, 2016, 0022-510X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.295

RIV identification code

RIV/00216224:14310/16:00088953

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.jns.2016.01.022

UT WoS

000372558400005

Keywords in English

Alzheimer's disease; Arachidonic acid; Association; Caffeic acid; Curcumin; FLAP; Genetics; Inflammation; Leukotrienes; Polymorphism

Abstract

V originále

Dementias of old age, in particular Alzheimer's disease (AD), pose a growing threat to the longevity and quality of life of individuals as well as whole societies world-wide. The risk factors are both genetic and environmental (life-style) and there is an overlap with similar factors predisposing to cardiovascular diseases (CVD). Using a case-control genetic approach, we have identified a SNP (rs10507391) in ALOX5 gene, previously associated with an increased risk of stroke, as a novel genetic risk factor for AD. ALOX5 gene encodes a 5-lipoxygenase (5-LO) activating protein (FLAP), a crucial component of the arachidonic acid/leukotriene inflammatory cascade. A-allele of rs4769874 polymorphism increases the risk of AD 1.41-fold (p = 0.0001), while AA genotype does so 1.79-fold (p = 0.0001). In addition, GG genotype of rs4769874 polymorphism is associated with a modest increase in body mass index (BMI). We discuss potential biochemical mechanisms linking the SNP to AD and suggest possible preventive pharmacotherapies some of which are based on commonly available natural products. Finally, we set the newly identified AD risk factors into a broader context of similar CVD risk factors to generate a more comprehensive picture of interacting genetics and life-style habits potentially leading to the deteriorating mental health in the old age.

Links

NT11152, research and development project

Name: Epidemiologie a genetika Alzheimerovy choroby

Citovat

ŠERÝ, Omar, Lýdia HLINECKÁ, Jana POVOVA, Ondřej BONCZEK, Tomáš ZEMAN, Vladimír JANOUT, Petr AMBROZ, Naim Akhtar KHAN and Vladimír Josef BALCAR. Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index. Journal of the neurological sciences. Netherlands: Amsterdam : Elsevier, 2016, vol. 362, March, p. 27-32. ISSN 0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2016.01.022.

@article{1376198,
   author = {Šerý, Omar and Hlinecká, Lýdia and Povova, Jana and Bonczek, Ondřej and Zeman, Tomáš and Janout, Vladimír and Ambroz, Petr and Khan, Naim Akhtar and Balcar, Vladimír Josef},
   article_location = {Netherlands},
   article_number = {March},
   doi = {http://dx.doi.org/10.1016/j.jns.2016.01.022},
   keywords = {Alzheimer's disease; Arachidonic acid; Association; Caffeic acid; Curcumin; FLAP; Genetics; Inflammation; Leukotrienes; Polymorphism},
   language = {eng},
   issn = {0022-510X},
   journal = {Journal of the neurological sciences},
   title = {Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index},
   volume = {362},
   year = {2016}
}

TY  - JOUR
ID  - 1376198
AU  - Šerý, Omar - Hlinecká, Lýdia - Povova, Jana - Bonczek, Ondřej - Zeman, Tomáš - Janout, Vladimír - Ambroz, Petr - Khan, Naim Akhtar - Balcar, Vladimír Josef
PY  - 2016
TI  - Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index
JF  - Journal of the neurological sciences
VL  - 362
IS  - March
SP  - 27-32
EP  - 27-32
PB  - Amsterdam : Elsevier
SN  - 0022510X
KW  - Alzheimer's disease
KW  - Arachidonic acid
KW  - Association
KW  - Caffeic acid
KW  - Curcumin
KW  - FLAP
KW  - Genetics
KW  - Inflammation
KW  - Leukotrienes
KW  - Polymorphism
N2  - Dementias of old age, in particular Alzheimer's disease (AD), pose a growing threat to the longevity and quality of life of individuals as well as whole societies world-wide. The risk factors are both genetic and environmental (life-style) and there is an overlap with similar factors predisposing to cardiovascular diseases (CVD). Using a case-control genetic approach, we have identified a SNP (rs10507391) in ALOX5 gene, previously associated with an increased risk of stroke, as a novel genetic risk factor for AD. ALOX5 gene encodes a 5-lipoxygenase (5-LO) activating protein (FLAP), a crucial component of the arachidonic acid/leukotriene inflammatory cascade. A-allele of rs4769874 polymorphism increases the risk of AD 1.41-fold (p = 0.0001), while AA genotype does so 1.79-fold (p = 0.0001). In addition, GG genotype of rs4769874 polymorphism is associated with a modest increase in body mass index (BMI). We discuss potential biochemical mechanisms linking the SNP to AD and suggest possible preventive pharmacotherapies some of which are based on commonly available natural products. Finally, we set the newly identified AD risk factors into a broader context of similar CVD risk factors to generate a more comprehensive picture of interacting genetics and life-style habits potentially leading to the deteriorating mental health in the old age.
ER  -

ŠERÝ, Omar, Lýdia HLINECKÁ, Jana POVOVA, Ondřej BONCZEK, Tomáš ZEMAN, Vladimír JANOUT, Petr AMBROZ, Naim Akhtar KHAN and Vladimír Josef BALCAR. Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index. \textit{Journal of the neurological sciences}. Netherlands: Amsterdam : Elsevier, 2016, vol.~362, March, p.~27-32. ISSN~0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2016.01.022.

Detailed Information on Publication Record