Detailed Information on Publication Record
2016
Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index
ŠERÝ, Omar, Lýdia HLINECKÁ, Jana POVOVA, Ondřej BONCZEK, Tomáš ZEMAN et. al.Basic information
Original name
Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index
Authors
ŠERÝ, Omar (203 Czech Republic, guarantor, belonging to the institution), Lýdia HLINECKÁ (203 Czech Republic, belonging to the institution), Jana POVOVA (203 Czech Republic), Ondřej BONCZEK (203 Czech Republic, belonging to the institution), Tomáš ZEMAN (203 Czech Republic, belonging to the institution), Vladimír JANOUT (203 Czech Republic), Petr AMBROZ (203 Czech Republic), Naim Akhtar KHAN (250 France) and Vladimír Josef BALCAR (36 Australia)
Edition
Journal of the neurological sciences, Netherlands, Amsterdam : Elsevier, 2016, 0022-510X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.295
RIV identification code
RIV/00216224:14310/16:00088953
Organization unit
Faculty of Science
UT WoS
000372558400005
Keywords in English
Alzheimer's disease; Arachidonic acid; Association; Caffeic acid; Curcumin; FLAP; Genetics; Inflammation; Leukotrienes; Polymorphism
Změněno: 30/3/2017 10:21, Ing. Andrea Mikešková
Abstract
V originále
Dementias of old age, in particular Alzheimer's disease (AD), pose a growing threat to the longevity and quality of life of individuals as well as whole societies world-wide. The risk factors are both genetic and environmental (life-style) and there is an overlap with similar factors predisposing to cardiovascular diseases (CVD). Using a case-control genetic approach, we have identified a SNP (rs10507391) in ALOX5 gene, previously associated with an increased risk of stroke, as a novel genetic risk factor for AD. ALOX5 gene encodes a 5-lipoxygenase (5-LO) activating protein (FLAP), a crucial component of the arachidonic acid/leukotriene inflammatory cascade. A-allele of rs4769874 polymorphism increases the risk of AD 1.41-fold (p = 0.0001), while AA genotype does so 1.79-fold (p = 0.0001). In addition, GG genotype of rs4769874 polymorphism is associated with a modest increase in body mass index (BMI). We discuss potential biochemical mechanisms linking the SNP to AD and suggest possible preventive pharmacotherapies some of which are based on commonly available natural products. Finally, we set the newly identified AD risk factors into a broader context of similar CVD risk factors to generate a more comprehensive picture of interacting genetics and life-style habits potentially leading to the deteriorating mental health in the old age.
Links
| NT11152, research and development project |
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