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@article{1376733,
author = {Vaulet, Lucía Gallo and Grillová, Linda and Mikalová, Lenka and Casco, Ricardo and Fermepin, Marcelo Rodríguez and Pando, María A. and Šmajs, David},
article_location = {San Francisco},
article_number = {2},
doi = {http://dx.doi.org/10.1371/journal.pone.0172905},
keywords = {SYPHILIS-CAUSING STRAINS; RIBOSOMAL-RNA A2058G; AZITHROMYCIN RESISTANCE; SAN-FRANCISCO; UNITED-STATES; TP0548 GENE; PREVALENCE; CHINA; EPIDEMIOLOGY; MUTATIONS},
language = {eng},
issn = {1932-6203},
journal = {Plos one},
title = {Molecular typing of Treponema pallidum isolates from Buenos Aires, Argentina: Frequent Nichols-like isolates and low levels of macrolide resistance},
volume = {12},
year = {2017}
}
TY - JOUR
ID - 1376733
AU - Vaulet, Lucía Gallo - Grillová, Linda - Mikalová, Lenka - Casco, Ricardo - Fermepin, Marcelo Rodríguez - Pando, María A. - Šmajs, David
PY - 2017
TI - Molecular typing of Treponema pallidum isolates from Buenos Aires, Argentina: Frequent Nichols-like isolates and low levels of macrolide resistance
JF - Plos one
VL - 12
IS - 2
SP - 1-14
EP - 1-14
PB - Public Library of Science
SN - 19326203
KW - SYPHILIS-CAUSING STRAINS
KW - RIBOSOMAL-RNA A2058G
KW - AZITHROMYCIN RESISTANCE
KW - SAN-FRANCISCO
KW - UNITED-STATES
KW - TP0548 GENE
KW - PREVALENCE
KW - CHINA
KW - EPIDEMIOLOGY
KW - MUTATIONS
N2 - A total of 54 clinical samples, including genital lesion swabs, whole blood and cerebrospinal fluid from patients diagnosed with syphilis were collected in 2006 and in 2013 in Buenos Aires, Argentina. Treponemal DNA was detected in 43 of the analyzed samples (79.6%) and further analyzed using Sequencing-based molecular typing (SBMT) and Enhanced CDC-typing (ECDCT). By SBMT, 10 different Treponema pallidum subsp. pallidum (TPA) genotypes were found, of which six were related to the TPA SS14 strain, and four to the TPA Nichols strain. The 23S rRNA gene was amplified in samples isolated from 42 patients, and in six of them (14.3%), either the A2058G (four patients, 9.5%) or the A2059G (two patients, 4.8%) mutations were found. In addition to Taiwan, Madagascar and Peru, Argentina is another country where the prevalence of Nichols-like isolates (26.8%) is greater than 10%.
ER -
VAULET, Lucía Gallo, Linda GRILLOVÁ, Lenka MIKALOVÁ, Ricardo CASCO, Marcelo Rodríguez FERMEPIN, María A. PANDO a David ŠMAJS. Molecular typing of Treponema pallidum isolates from Buenos Aires, Argentina: Frequent Nichols-like isolates and low levels of macrolide resistance. \textit{Plos one}. San Francisco: Public Library of Science, roč.~12, č.~2, s.~1-14. ISSN~1932-6203. doi:10.1371/journal.pone.0172905. 2017.
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