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@article{1376792, author = {Plevka, Pavel and Battisti, Anthony J. and Sheng, Ju and Rossmann, Michael G.}, article_location = {UNITED STATES}, article_number = {1}, doi = {http://dx.doi.org/10.1016/j.jsb.2013.11.001}, keywords = {Flavivirus; Dengue; Maturation; Symmetry; Icosahedron; Mismatch}, language = {eng}, issn = {1047-8477}, journal = {Journal of Structural Biology}, title = {Mechanism for maturation-related reorganization of flavivirus glycoproteins}, volume = {185}, year = {2014} }
TY - JOUR ID - 1376792 AU - Plevka, Pavel - Battisti, Anthony J. - Sheng, Ju - Rossmann, Michael G. PY - 2014 TI - Mechanism for maturation-related reorganization of flavivirus glycoproteins JF - Journal of Structural Biology VL - 185 IS - 1 SP - 27-31 EP - 27-31 PB - ACADEMIC PRESS INC ELSEVIER SCIENCE SN - 10478477 KW - Flavivirus KW - Dengue KW - Maturation KW - Symmetry KW - Icosahedron KW - Mismatch N2 - Flaviviruses, such as dengue, West Nile, and yellow fever viruses, assemble as fusion-incompetent particles and subsequently undergo a large reorganization of their glycoprotein envelope resulting in formation of mature infectious virions. Here we used a combination of three-dimensional cryo-electron tomography and two-dimensional image analysis to study pleomorphic maturation intermediates of dengue virus 2. Icosahedral symmetries of immature and mature regions within one particle were mismatched relative to each other. Furthermore, the orientation of the two regions relative to each other differed among particles. Therefore, there cannot be a specific pathway determining the maturation of all particles. Instead, the region with mature structure expands when glycoproteins on its boundary acquire suitable orientation and conformation to allow them to become a stable part of the mature region. This type of maturation is possible because the envelope glycoproteins are anchored to the phospholipid bilayer that is a part of flavivirus virions and are thus restricted to movement on the two-dimensional surface of the particle. Therefore, compounds that limit movement of the glycoproteins within the virus membrane might be used as inhibitors of flavivirus maturation. (C) 2013 Elsevier Inc. All rights reserved. ER -
PLEVKA, Pavel, Anthony J. BATTISTI, Ju SHENG and Michael G. ROSSMANN. Mechanism for maturation-related reorganization of flavivirus glycoproteins. \textit{Journal of Structural Biology}. UNITED STATES: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2014, vol.~185, No~1, p.~27-31. ISSN~1047-8477. Available from: https://dx.doi.org/10.1016/j.jsb.2013.11.001.
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