| PLEVKA, Pavel, Rushika PERERA, Moh Lan YAP, Jane CARDOSA, Richard KUHN and Michael G. ROSSMANN. Structure of human enterovirus 71 in complex with a capsid-binding inhibitor. Proceedings of the National Academy of Sciences of the United States of America. WASHINGTON: National Academy of Sciences, 2013, vol. 110, No 14, p. 5463-5467. ISSN 0027-8424. Available from: https://dx.doi.org/10.1073/pnas.1222379110. |
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@article{1376802,
author = {Plevka, Pavel and Perera, Rushika and Yap, Moh Lan and Cardosa, Jane and Kuhn, Richard and Rossmann, Michael G.},
article_location = {WASHINGTON},
article_number = {14},
doi = {http://dx.doi.org/10.1073/pnas.1222379110},
keywords = {stability; virus},
language = {eng},
issn = {0027-8424},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
title = {Structure of human enterovirus 71 in complex with a capsid-binding inhibitor},
volume = {110},
year = {2013}
}
TY - JOUR
ID - 1376802
AU - Plevka, Pavel - Perera, Rushika - Yap, Moh Lan - Cardosa, Jane - Kuhn, Richard - Rossmann, Michael G.
PY - 2013
TI - Structure of human enterovirus 71 in complex with a capsid-binding inhibitor
JF - Proceedings of the National Academy of Sciences of the United States of America
VL - 110
IS - 14
SP - 5463-5467
EP - 5463-5467
PB - National Academy of Sciences
SN - 00278424
KW - stability
KW - virus
N2 - Human enterovirus 71 is a picornavirus causing hand, foot, and mouth disease that may progress to fatal encephalitis in infants and small children. As of now, no cure is available for enterovirus 71 infections. Small molecule inhibitors binding into a hydrophobic pocket within capsid viral protein 1 were previously shown to effectively limit infectivity of many picornaviruses. Here we report a 3.2-angstrom-resolution X-ray structure of the enterovirus 71 virion complexed with the capsid-binding inhibitor WIN 51711. The inhibitor replaced the natural pocket factor within the viral protein 1 pocket without inducing any detectable rearrangements in the structure of the capsid. Furthermore, we show that the compound stabilizes enterovirus 71 virions and limits its infectivity, probably through restricting dynamics of the capsid necessary for genome release. Thus, our results provide a structural basis for development of antienterovirus 71 capsid-binding drugs.
ER -
PLEVKA, Pavel, Rushika PERERA, Moh Lan YAP, Jane CARDOSA, Richard KUHN and Michael G. ROSSMANN. Structure of human enterovirus 71 in complex with a capsid-binding inhibitor. \textit{Proceedings of the National Academy of Sciences of the United States of America}. WASHINGTON: National Academy of Sciences, 2013, vol.~110, No~14, p.~5463-5467. ISSN~0027-8424. Available from: https://dx.doi.org/10.1073/pnas.1222379110.
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