| PLEVKA, Pavel, Rushika PERERA, Jane CARDOSA, Richard J. KUHN and Michael G. ROSSMANN. Crystal Structure of Human Enterovirus 71. Science. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE, 2012, vol. 336, No 6086, p. 1274. ISSN 0036-8075. Available from: https://dx.doi.org/10.1126/science.1218713. |
Other formats:
BibTeX
LaTeX
RIS
@article{1376816,
author = {Plevka, Pavel and Perera, Rushika and Cardosa, Jane and Kuhn, Richard J. and Rossmann, Michael G.},
article_location = {WASHINGTON},
article_number = {6086},
doi = {http://dx.doi.org/10.1126/science.1218713},
keywords = {PICORNAVIRUS; RECEPTOR; DISEASE},
language = {eng},
issn = {0036-8075},
journal = {Science},
title = {Crystal Structure of Human Enterovirus 71},
volume = {336},
year = {2012}
}
TY - JOUR
ID - 1376816
AU - Plevka, Pavel - Perera, Rushika - Cardosa, Jane - Kuhn, Richard J. - Rossmann, Michael G.
PY - 2012
TI - Crystal Structure of Human Enterovirus 71
JF - Science
VL - 336
IS - 6086
SP - 1274
EP - 1274
PB - AMER ASSOC ADVANCEMENT SCIENCE
SN - 00368075
KW - PICORNAVIRUS
KW - RECEPTOR
KW - DISEASE
N2 - Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the “pocket factor,” a small molecule that stabilizes the virus, is partly exposed on the floor of the “canyon.” Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket.
ER -
PLEVKA, Pavel, Rushika PERERA, Jane CARDOSA, Richard J. KUHN and Michael G. ROSSMANN. Crystal Structure of Human Enterovirus 71. \textit{Science}. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE, 2012, vol.~336, No~6086, p.~1274. ISSN~0036-8075. Available from: https://dx.doi.org/10.1126/science.1218713.
|
