Crystal Structure of Human Enterovirus 71

PLEVKA, Pavel, Rushika PERERA, Jane CARDOSA, Richard J. KUHN and Michael G. ROSSMANN. Crystal Structure of Human Enterovirus 71. Science. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE, 2012, vol. 336, No 6086, p. 1274. ISSN 0036-8075. Available from: https://dx.doi.org/10.1126/science.1218713.

Basic information

Original name

Crystal Structure of Human Enterovirus 71

Authors

PLEVKA, Pavel, Rushika PERERA, Jane CARDOSA, Richard J. KUHN and Michael G. ROSSMANN

Edition

Science, WASHINGTON, AMER ASSOC ADVANCEMENT SCIENCE, 2012, 0036-8075

---

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 31.027

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1126/science.1218713

UT WoS

000304905300037

Keywords in English

PICORNAVIRUS; RECEPTOR; DISEASE

Tags

neMU

---

Abstract

V originále

Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the “pocket factor,” a small molecule that stabilizes the virus, is partly exposed on the floor of the “canyon.” Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket.