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@article{1377567,
author = {Volný, Ondřej and Cimflová, Petra and Lee, T.andY. and Menon, B. K. and d'Esterre, C. D.},
article_location = {Amsterdam},
article_number = {"neuvedeno"},
doi = {http://dx.doi.org/10.1016/j.jns.2017.03.035},
keywords = {Ischemic stroke; Malignant brain edema; CT perfusion; Permeability surface area product},
language = {eng},
issn = {0022-510X},
journal = {Journal of the Neurological Sciences},
title = {Permeability surface area product analysis in malignant brain edema prediction – A pilot study},
url = {http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005434},
volume = {376},
year = {2017}
}
TY - JOUR
ID - 1377567
AU - Volný, Ondřej - Cimflová, Petra - Lee, T.-Y. - Menon, B. K. - d'Esterre, C. D.
PY - 2017
TI - Permeability surface area product analysis in malignant brain edema prediction – A pilot study
JF - Journal of the Neurological Sciences
VL - 376
IS - "neuvedeno"
SP - 206-210
EP - 206-210
PB - Elsevier Science BV
SN - 0022510X
KW - Ischemic stroke
KW - Malignant brain edema
KW - CT perfusion
KW - Permeability surface area product
UR - http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005434
N2 - Background and purpose Using an extended CT perfusion acquisition (150s), we sought to determine the association between perfusion parameters and malignant edema after ischemic stroke. Methods Patients (from prospective study PROVE-IT, NCT02184936) with terminal internal carotid artery ± proximal middle cerebral occlusion were involved. CTA was assessed for clot location and status of leptomeningeal collaterals. The following CTP parameters were calculated within the ischemic territory and contralaterally: permeability surface area product (PS), cerebral blood flow (CBF) and cerebral blood volume (CBV). PS was calculated using the adiabatic approximation to the Johnson and Wilson model. Outcome was evaluated by midline shift and infarction volume on follow-up imaging. Results Of 200 patients enrolled, 7 patients (3.5%) had midline shift >= 5 mm (2 excluded for poor-quality scans). Five patients with midline shift and 5 matched controls were analysed. There was no significant difference in mean PS, CBF and CBV within the ischemic territory between the two groups. A CBV threshold of 1.7 ml/100 g had the highest AUC = 0.72, 95% CI = 0.54–0.90 for early midline shift prediction, sensitivity and specificity were 0.83 and 0.67 respectively. Conclusion Our preliminary results did not show significant differences in permeability surface area analysis if analysed for complete ischemic region. CBV parameter had the highest accuracy and there was a trend for the mean PS values for midline shift prediction.
ER -
VOLNÝ, Ondřej, Petra CIMFLOVÁ, T.-Y. LEE, B. K. MENON and C. D. D'ESTERRE. Permeability surface area product analysis in malignant brain edema prediction – A pilot study. \textit{Journal of the Neurological Sciences}. Amsterdam: Elsevier Science BV, 2017, vol.~376, ''neuvedeno'', p.~206-210. ISSN~0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2017.03.035.
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