Differential characteristics of ketamine self-administration in
the olfactory bulbectomy model of depression in male rats

J 2017

Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats

BABINSKÁ, Zuzana and Jana RUDÁ

Basic information

Original name

Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats

Authors

BABINSKÁ, Zuzana (703 Slovakia, belonging to the institution) and Jana RUDÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Experimental and Clinical Psychopharmacology, Washington, American Psychological Association Inc. 2017, 1064-1297

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.354

RIV identification code

RIV/00216224:14110/17:00096469

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1037/pha0000106

UT WoS

000397860400004

Keywords in English

Depression; Ketamine; Olfactory bulbectomy; Self-administration; Wistar rats

Abstract

V originále

Ketamine has been extensively studied for its antidepressant potential, with promising results in both preclinical and clinical studies. However, concerns regarding its abuse liabilities greatly limit its potential to become an approved treatment for depression. Therefore, a better understanding the risks and benefits of ketamine use in depression is needed. This study aimed to assess the characteristics of operant intravenous (IV) ketamine self-administration and relapse-like behavior in the olfactory bulbectomy (OBX) model of depression in male rats. Twenty-five male Wistar rats were divided randomly into 2 groups; in 1 group the bilateral olfactory bulbectomy was performed, whereas the other group was sham-operated. Intravenous self-administration of ketamine (.5 mg/kg/infusion) was conducted under a fixed ratio 1 schedule of reinforcement. After reaching stable drug intakes, rats then underwent a 14-day period of forced abstinence followed by a drug-free relapse-like session. The forced swim test was conducted before the commencement of the self-administration protocol and on the 1st day of abstinence. Consistent with findings in previous studies on other substances, OBX animals showed increased operant IV ketamine self-administration. In contrast, ketamine-seeking behavior in the OBX group did not differ from sham-operated animals during the relapse-like session, whereas previous studies on other psychostimulants like methamphetamine and cocaine reported increases. Our findings suggest substantially different underlying neuroadaptations between chronic ketamine and psychostimulant exposure.

Links

MUNI/A/1284/2015, interní kód MU

Name: Experimentální farmakologický vývoj v neuropsychiatrii a onkologii

Investor: Masaryk University, Category A

ROZV/24/LF/2016, interní kód MU

Name: LF - Příspěvek IP 2016

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

BABINSKÁ, Zuzana and Jana RUDÁ. Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats. Experimental and Clinical Psychopharmacology. Washington: American Psychological Association Inc., 2017, vol. 25, No 2, p. 84-93. ISSN 1064-1297. Available from: https://dx.doi.org/10.1037/pha0000106.

@article{1378142,
   author = {Babinská, Zuzana and Rudá, Jana},
   article_location = {Washington},
   article_number = {2},
   doi = {http://dx.doi.org/10.1037/pha0000106},
   keywords = {Depression; Ketamine; Olfactory bulbectomy; Self-administration; Wistar rats},
   language = {eng},
   issn = {1064-1297},
   journal = {Experimental and Clinical Psychopharmacology},
   title = {Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats},
   volume = {25},
   year = {2017}
}

TY  - JOUR
ID  - 1378142
AU  - Babinská, Zuzana - Rudá, Jana
PY  - 2017
TI  - Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats
JF  - Experimental and Clinical Psychopharmacology
VL  - 25
IS  - 2
SP  - 84-93
EP  - 84-93
PB  - American Psychological Association Inc.
SN  - 10641297
KW  - Depression
KW  - Ketamine
KW  - Olfactory bulbectomy
KW  - Self-administration
KW  - Wistar rats
N2  - Ketamine has been extensively studied for its antidepressant potential, with promising results in both preclinical and clinical studies. However, concerns regarding its abuse liabilities greatly limit its potential to become an approved treatment for depression. Therefore, a better understanding the risks and benefits of ketamine use in depression is needed. This study aimed to assess the characteristics of operant intravenous (IV) ketamine self-administration and relapse-like behavior in the olfactory bulbectomy (OBX) model of depression in male rats. Twenty-five male Wistar rats were divided randomly into 2 groups; in 1 group the bilateral olfactory bulbectomy was performed, whereas the other group was sham-operated. Intravenous self-administration of ketamine (.5 mg/kg/infusion) was conducted under a fixed ratio 1 schedule of reinforcement. After reaching stable drug intakes, rats then underwent a 14-day period of forced abstinence followed by a drug-free relapse-like session. The forced swim test was conducted before the commencement of the self-administration protocol and on the 1st day of abstinence. Consistent with findings in previous studies on other substances, OBX animals showed increased operant IV ketamine self-administration. In contrast, ketamine-seeking behavior in the OBX group did not differ from sham-operated animals during the relapse-like session, whereas previous studies on other psychostimulants like methamphetamine and cocaine reported increases. Our findings suggest substantially different underlying neuroadaptations between chronic ketamine and psychostimulant exposure.
ER  -

BABINSKÁ, Zuzana and Jana RUDÁ. Differential characteristics of ketamine self-administration in the olfactory bulbectomy model of depression in male rats. \textit{Experimental and Clinical Psychopharmacology}. Washington: American Psychological Association Inc., 2017, vol.~25, No~2, p.~84-93. ISSN~1064-1297. Available from: https://dx.doi.org/10.1037/pha0000106.

Detailed Information on Publication Record