Vaccine-driven evolution of parasite virulence and immune
evasion in age-structured population: the case of pertussis

J 2016

Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis

BERNHAUEROVÁ, Veronika

Basic information

Original name

Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis

Authors

BERNHAUEROVÁ, Veronika (203 Czech Republic, guarantor, belonging to the institution)

Edition

Theoretical Ecology, HEIDELBERG, SPRINGER HEIDELBERG, 2016, 1874-1738

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Full Text

Impact factor

Impact factor: 1.221

RIV identification code

RIV/00216224:14310/16:00094238

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1007/s12080-016-0300-5

UT WoS

000388954400005

Keywords in English

Age-structured model; Adaptive dynamics; Bordetella pertussis; Immune evasion; Vaccination; Virulence

Abstract

V originále

Despite enormous success of mass immunization programs in reducing incidence of infectious diseases, vaccine-escape strains have emerged perhaps as a consequence of strong selection pressures exerted on parasites by vaccines. Pertussis presents a well-documented example. As a childhood infection, it exhibits age-specific transmission biased to children. Assuming different transmission rates between children and adults, I study, by means of an age-structured epidemic model, evolutionary dynamics of parasite virulence in a vaccinated population. I find that the age-structure does not affect the evolutionary dynamics of parasite virulence. Also, based on empirical data reporting antigenic divergence with vaccine strains and mutations in virulence-associated genes in pertussis populations, I allow for parallel occurrence of mutations in parasite virulence and associated immune evasion. I conclude that this simultaneous adaptation of both traits may substantially alter the evolutionary course of the parasite. In particular, higher values of virulence are favoured once the parasite is able to evade the transmission-blocking vaccine-induced immunity. On the other hand, lower values of virulence are selected for once the parasite evolves the ability to evade the virulence-blocking vaccine-induced immunity. I emphasize the importance of multi-trait evolution to assess the direction of parasite adaptation more accurately.

Links

MUNI/A/1441/2014, interní kód MU

Name: Matematické a statistické modely (Acronym: Matematické a statistické modely)

Investor: Masaryk University, Category A

Citovat

BERNHAUEROVÁ, Veronika. Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis. Theoretical Ecology. HEIDELBERG: SPRINGER HEIDELBERG, 2016, vol. 9, No 4, p. 431-442. ISSN 1874-1738. Available from: https://dx.doi.org/10.1007/s12080-016-0300-5.

@article{1380300,
   author = {Bernhauerová, Veronika},
   article_location = {HEIDELBERG},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s12080-016-0300-5},
   keywords = {Age-structured model; Adaptive dynamics; Bordetella pertussis; Immune evasion; Vaccination; Virulence},
   language = {eng},
   issn = {1874-1738},
   journal = {Theoretical Ecology},
   title = {Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis},
   url = {https://link.springer.com/content/pdf/10.1007/s12080-016-0300-5.pdf},
   volume = {9},
   year = {2016}
}

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AU  - Bernhauerová, Veronika
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TI  - Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis
JF  - Theoretical Ecology
VL  - 9
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SP  - 431-442
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PB  - SPRINGER HEIDELBERG
SN  - 18741738
KW  - Age-structured model
KW  - Adaptive dynamics
KW  - Bordetella pertussis
KW  - Immune evasion
KW  - Vaccination
KW  - Virulence
UR  - https://link.springer.com/content/pdf/10.1007/s12080-016-0300-5.pdf
L2  - https://link.springer.com/content/pdf/10.1007/s12080-016-0300-5.pdf
N2  - Despite enormous success of mass immunization programs in reducing incidence of infectious diseases, vaccine-escape strains have emerged perhaps as a consequence of strong selection pressures exerted on parasites by vaccines. Pertussis presents a well-documented example. As a childhood infection, it exhibits age-specific transmission biased to children. Assuming different transmission rates between children and adults, I study, by means of an age-structured epidemic model, evolutionary dynamics of parasite virulence in a vaccinated population. I find that the age-structure does not affect the evolutionary dynamics of parasite virulence. Also, based on empirical data reporting antigenic divergence with vaccine strains and mutations in virulence-associated genes in pertussis populations, I allow for parallel occurrence of mutations in parasite virulence and associated immune evasion. I conclude that this simultaneous adaptation of both traits may substantially alter the evolutionary course of the parasite. In particular, higher values of virulence are favoured once the parasite is able to evade the transmission-blocking vaccine-induced immunity. On the other hand, lower values of virulence are selected for once the parasite evolves the ability to evade the virulence-blocking vaccine-induced immunity. I emphasize the importance of multi-trait evolution to assess the direction of parasite adaptation more accurately.
ER  -

BERNHAUEROVÁ, Veronika. Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis. \textit{Theoretical Ecology}. HEIDELBERG: SPRINGER HEIDELBERG, 2016, vol.~9, No~4, p.~431-442. ISSN~1874-1738. Available from: https://dx.doi.org/10.1007/s12080-016-0300-5.

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